Using a model previously published, predictions for evolution of conversion and average particle diameter in batch experiments are compared against experimental data for four emulsion copolymerizations of styrene with the following monomers: (1) methyl methacrylate, (2) butyl acrylate, (3) butadiene, and (4) acrylic acid. For each copolymerization system the experiments covered simultaneous variations in five variables: initiator and surfactant concentrations, water to monomer ratio, monomer composition, and temperature. It is shown that after data fitting for unknown or uncertain parameters, the model is capable of explaining quantitatively the experimental observations for conversion evolution and only qualitatively the particle size evolution data. This points out to the possible contribution of particle nucleation mechanisms other than the micellar one, which is the only mechanism included in the model. Some of the adjustable parameter values were found to depend on the copolymer composition. The only case in which the model does not perform well is in the prediction of the effect of initiator concentration on the copolymerization rate for butadiene-rich formulations. It is also found that the model predictions are very sensitive to the value of the diffusion coefficients of monomeric radicals in the copolymer particle, which are not readily available in the literature. It is concluded that it is important to independently measure these parameters in order to enhance the predictive power of models. It is also concluded that the model can be useful for practical applications.