Korean Journal of Chemical Engineering, Vol.17, No.6, 672-677, November, 2000
Effects of Basic Modifiers on SFE Efficiencies of Ephedrine Derivatives from Plant Matrix
E-mail:
The effect of basified modifiers in supercritical CO2 (SCF-CO2) such as diethylamine has been investigated on the SFE efficiencies of ephedrine derivatives (e.g. methylephedrine, norephedrine, ephedrine, and pseudoephedrine) from aerial parts of Ephedra sinica. The addition of basified modifiers in SCF-CO2 showed a greater enhancement of SFE efficiency of ephedrine derivatives than pure modifiers. These results might be due to the fact that the salts of Ephedra alkaloids (insoluble in CO2) in plant tissues would be changed to their free bases (freely soluble in CO2) by basified modifiers such as diethylamine in methanol. In addition to enhancing the solubilities, it could increase the degree of desorption of the compounds from plant matrix. Also, the SCF-CO2 modified with methanol basified with diethylamine showed a difference of extractability of ephedrine and its diastereomer, pseudoephedrine.
- Bicchi C, Rubiolo P, Frattini C, Sandra P, David F, J. Nat. Prod., 54, 941 (1991)
- Bugatti C, Colombo ML, Mossa A, Planta Med., 59, 626 (1993)
- Elisabeth P, Yoshioka M, Yamauchi Y, Saito M, Anal. Sci., 7, 427 (1991)
- Fahmy TM, Paulaitis ME, Johnson DM, McNally MEP, Anal. Chem., 65, 1462 (1993)
- Janicot JL, Caude M, Rosset R, J. Chromatogr., 505, 247 (1990)
- Moore WN, Taylor LT, J. Nat. Prod., 59, 690 (1996)
- Ndiomu DP, Simpson CF, Anal. Chim. Acta, 213, 237 (1988)
- Shaeffer ST, Zalkow LH, Teja AS, Ind. Eng. Chem. Res., 28, 1017 (1989)
- Sugiyama K, Saito M, Hondo T, Senda M, J. Chromatogr., 332, 107 (1985)
- Tang W, Eisenbrand G, "Chinese Drugs of Plant Origin," Springer Verlag, New York, 481 (1992)
- Tyler VE, Brady LR, Robbers JE, "Pharmacognosy," 8th ed.; Lea & Febiger: Philadelphia, Chapter, 8, 195 (1981)
- Zhang J, Tian Z, Lou Z, Planta Med., 54, 69 (1988)