Oxazepam is a drug characterised by its marked hydrophobicity and unsatisfactory wettability on contact with wafer. These properties lead to incomplete absorption of the drug from the gastrointestinal tract when the pharmaceutical dosage form is not adequately formulated. For this reason, it is of interest to optimise its dissolution properties. For this purpose, the preparation of solid dispersions with hydrophilic carriers has been often employed. In this paper, the possibility of employing two hydrophilic substances (PEG 6000 and D-mannitol) as carriers for solid dispersions, prepared by the co-fusion or the fusion carrier methods, were evaluated by DSC and HSM. The results show, in terms of the miscibility of molten oxazepam in the fused vehicle, that PEG 6000 is the only suitable carrier. D-mannitol yielded non-homogeneous systems.