The previously developed approach [16] to predicting excess enthalpies of binary mixtures from infinite dilution activity coefficients has been applied to 1-alkanol + n-alkane systems. The predicted results of excess enthalpies for 49 1-alkanol + n-alkane systems are in good agreement with the literature experimental data; the considered systems include a wide range of molecular sizes for both 1-alkanol (from methanol) and n-alkane (from pentane to hexadecane).