This paper sums up the possible application of controlled rate thermal analysis methods to study liquid-solid interactions and the physicochemical properties of liquid films and solid surfaces, using mainly the programmed thermodesorption of liquid from the sample. The results prove the applicability of this approach in the determination of adsorption value, thermodynamic functions, properties of adsorbed layers and the heterogeneity of porous materials. One principal idea of these studies was to register the effects taking place in processes opposite to adsorption, i.e. in the controlled rate thermodesorption of liquids from solid surfaces. The method utilized the differential time and temperature weight-loss (DTG) dependences of the thermogravimetric (TGA) curves as well as the differential scanning calorimetry (DSC) curves obtained during cooling and heating at subambient and elevated temperatures. It can be concluded that thermal analysis is a simple, useful and effective method, besides its classical applications, in characterizing liquid-solid systems. The author’s most important results have been evaluated and published, or submitted for publication, in this and other scientific journals over the last past decade.