A chemical association model based on mole fraction statistics is used to predict the ternary excess molar enthalpies of the n-butylamine + 1,4-dioxane + acetonitrile system using only binary parameters derived from excess molar enthalpy data for its three constituent binary systems. The model assumes that the self-association of n-butylamine and acetonitrile, the solvation between unlike molecules and the binary non-specific molecular interactions between the components are given by the NRTL equation.