Science, Vol.274, No.5295, 2054-2057, 1996
Late Complications of Immune Deviation Therapy in a Nonhuman Primate
The administration of antigens in soluble form can induce antigen-specific immune tolerance and suppress experimental autoimmune diseases, In a marmoset model of multiple sclerosis induced by myelin oligodendrocyte glycoprotein (MOG), marmosets tolerized to MOG were protected against acute disease, but after tolerization treatment a lethal demyelinating disorder emerged. In these animals, MOG-specific T cell proliferative responses were transiently suppressed, cytokine production was shifted from a T helper type 1 (T(H)1) to a T(H)2 pattern, and titers of autoantibodies to MOG were enhanced. Thus, immune deviation can increase concentrations of pathogenic autoantibodies and in some circumstances exacerbate autoimmune disease.
Keywords:MYELIN BASIC-PROTEIN;EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS;EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS;T-CELL CLONES;MULTIPLE-SCLEROSIS;OLIGODENDROCYTE GLYCOPROTEIN;DEMYELINATING DISEASES;EXPRESSION;CYTOKINES;INVITRO