In order to compatibilize polysulfone/polyamide-blends by reactive blending melt blending studies using polysulfones with different functional groups (carboxyl-, anhydride) and polyamide were performed in a batch-type mixer. The obtained materials were investigated by solvent extraction and transmission electron microscopy. Model experiments reveal the possibilty to compatibilize polysulfone/polyamide-blends by reactive blending techniques using functionalized polysulfones. Extraction studies as well as the morphologies of the prepared samples give evidence for a copolymer formation during the melt blending experiments.