The distribution of microelements in different types of crude oil from the Paleocene-Eocene deposits of the Afghan-Tadzhik Depression has been examined, and their metal content assessed. Abnormally high concentrations of a number of microelements in crude oils of the Afghan-Tadzhik Depression have been established, considerably higher than the crustal abundances of the same elements in clay rock. The main role in the enrichment of crude oils with microelements is attributed to processes of their hypergenetic conversion, since ore-bearing concentrations of microelements are connected with high-viscosity, heavy, resinous crude oils. Crude oils of the Afghan-Tadzhik Depression may be used as an alternative source of metals such as vanadium, nickel, copper, chromium, cobalt and, possibly, others.