Nature, Vol.387, No.6628, 49-55, 1997
Role for N-Cor and Histone Deacetylase in Sin3-Mediated Transcriptional Repression
Normal mammalian growth and development ave highly dependent on the regulation of the expression and activity of the Myo family of transcription factors. Mxi1-mediated inhibition of Myc activities requires interaction with mammalian Sin3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxi1/Sin3-induced transcriptional repression and tumour suppression.
Keywords:THYROID-HORMONE RECEPTOR;MYC TRANSGENIC MICE;SACCHAROMYCES-CEREVISIAE;CHROMATIN STRUCTURE;YEAST;PROTEIN;ACTIVATION;COMPLEX;DOMAIN;GENES