Nature, Vol.374, No.6518, 131-134, 1995
Principles of Cdk Regulation
As hey regulators of the cell cycle, the cyclin-dependent kinases must be tightly regulated by extra- and intracellular signals. The activity of cyclin-dependent kinases is controlled by four highly conserved biochemical mechanisms, forming a web of regulatory pathways unmatched in its elegance and intricacy.
Keywords:CYCLIN-DEPENDENT KINASES;WEE1 TYROSINE KINASE;YEAST-CELL CYCLE;PROTEIN-KINASE;NEGATIVE REGULATION;G1 CYCLIN;SACCHAROMYCES-CEREVISIAE;CATALYTIC SUBUNIT;PHOSPHORYLATION;INHIBITOR