The reactivities of cis and trans isomers of 1,2-diaminocyclohexane (1,2-DCH)/epoxy resin were studied separately. We found that the primary amine hydrogen disappears in both isomers at a similar rate when they react with an epoxy resin. However, the formation of tertiary amines differs considerably. The reactivity of the second amine hydrogen for the trans isomer is greater than that for the cis isomer, and this difference is observed as the reaction proceeds. The main reason for the slower disappearance of the cis secondary amine is steric hindrance and this fact is observed in the preexponential factors, glass transition temperatures (T-g), and ratio of rate constants of secondary to primary amine (R). The reaction was followed by Fourier transform infrared spectroscopy in the near-infrared range. The values of T-g were obtained by differential scanning calorimetry.