The possibility for industrialization of the catalytic Multistage Fixed Bed Tower (MFBT) bioreactor using the mineral kissiris as a promoting material is examined in a large-scale pilot plant using 7000 and 100,000 L bioreactors separately. The stability of kissiris’ structure, the viability of culture, and the formation of volatile compounds were studied from batch to batch. This mineral, being a volcanic and foaming silicious rock with an average cost of $60/t, was examined by X-ray defractometer and found to mainly consist of anorthite. The stability of the catalyst not being infected was studied by an electron microscope and the viability of culture was estimated by the percentage of dead cells and the percentage of bacteria. Therefore, viability of culture was at a good level and the structure of catalyst, as related with low-residual sugar, remained constant from batch to batch, even after a preservation process of at least 6 mo. Likewise, ethyl-acetate was increased and higher alcohols were decreased in the overall period of experiments.