화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.46, No.3, 301-317, May, 2022
DOI10.7317/pk.2022.46.3.301  Export Citation
조직공학에서의 3D 바이오프린팅 기술의 잠재력
Potential of 3D Bioprinting Techniques in Tissue Engineering
고윤제, 김천호1, 권오형†
  • 금오공과대학교 고분자공학과
  • 1한국원자력의학원 조직공학연구실
Yunjeh Ko, Chun-Ho Kim1, and Oh Hyeong Kwon†
  • Department of Polymer Science and Engineering, Kumoh National Institute of Technology, Gumi, Gyeongbuk 39177, Korea
  • 1Laboratory of Tissue Engineering, Korea Institute of Radiological and Medical Sciences, Nowon, Seoul 01812, Korea
E-mail:
초록
3차원(3D) 바이오프린팅은 세포를 함유한 생물학적 구조물의 입체적 조형에 사용되는 적층제작술이다. 특히, CAD(computer-aided design)와 3축 출력기구 및 세포를 함유한 최적의 물리화학적 바이오잉크를 사용하여 정확하 고 균일한 구조의 맞춤형 인공조직(뼈/연골, 피부/근육, 혈관, 장기 시스템)을 제작할 수 있다. 바이오프린팅의 주요 절차는 모델링, 고체 자유형상 제작 및 후성숙의 세 단계로 진행된다. 본 리뷰에서는 3D 바이오프린팅의 기본원리, 구성요소 및 잠재력 있는 연구사례들을 소개하고 실제적인 조직공학 및 의료적 응용분야에서의 도전과제를 요약하였다.
Three-dimensional (3D) bioprinting is an additive manufacturing technique used for the 3D modeling of biological constructs containing cells. In particular, customized artificial tissues (bone/cartilage, skin/muscle, blood vessels, organs system) with precise and uniform structures can be created using computer-aided design, 3-axis plotting instrument, and optimum physicochemical cell-laden bioinks. The main bioprinting procedures are three stages of modeling, solid freeform fabrication, and post-maturation. This review introduced the basic principles and components of 3D bioprinting and potential research cases to summarize the challenging agenda in practical tissue engineering and medical applications.
Keywords:additive manufacturing;3D bioprinting;bioink;tissue engineering;medical
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