Oxidized gum arabic cross-linked pectin/O-carboxymethyl chitosan: An antibiotic adsorbent hydrogel

Reza Darvishi; Hajar Moghadas; Ali Moshkriz

Korean Journal of Chemical Engineering, Vol.39, No.5, 1350-1360, May, 2022

DOI10.1007/s11814-021-1038-3 Export Citation

Oxidized gum arabic cross-linked pectin/O-carboxymethyl chitosan: An antibiotic adsorbent hydrogel

Reza Darvishi^†, Hajar Moghadas, and Ali Moshkriz¹

Department of Gas and Petroleum, Yasouj University, Gachsaran, 75918-74831, Iran
¹Department of Chemical Engineering, Faculty of Engineering, Arak University, Arak, 38156-8-8349, Iran

E-mail:

The current work investigated the synthesis possibility of oxidized gum arabic cross-linked pectin/O-carboxymethyl chitosan hydrogels (OGA-Pc-O-CMCS) as a pH-sensitive adsorbent vehicle. During the hydrogel fabrication, the cross-linker oxidized gum arabic (OGA) plays an important role in the enhancement of mechanical stability and the structural compactness of the hydrogel. The effect of OGA content, reaction time, reaction temperature, and reaction pH on the hydrogel swelling and crosslink degree was evaluated, modeled, and optimized statistically using response surface methodology (RSM) based on central composite design (CCD). As the pH of pectin/O-Carboxymethyl chitosan (Pc-O-CMCS) complexation increased up to 6.0, the swelling degree of the hydrogels decreased regardless of the concentration of the OGA. The swelling indices of 101.35% and 70.552% showed the optimum RSM results in the acidic and neutral medium, respectively. The adsorption efficiency of two conventional fluoroquinolones antibiotics (Levofloxacin (LVX) and Delafloxacin (DLX)) in the optimized hydrogel formulations was investigated. The obtained results confirmed that OGA concentration was an important parameter in the swelling processes. The adsorption capacity of the hydrogels was higher in acidic medium (pH 3.9) compared to natural medium (pH 7.1), which indicates the pH-sensitive adsorption behavior of the prepared hydrogel. The maximum antibiotic adsorption occurred after 12 hours: (66.3-87.5%) and (45-53%) for pH 3.9 and 7.1, respectively. The shape and morphological analysis of the beads before and after adsorption was performed using field emission scanning electron microscopy (FE-SEM). The FE-SEM analysis revealed that the shape of the beads changed significantly because of erosion and swelling activity after antibiotics adsorption. Experimental results exhibited that SIP model fitted best to the isotherm adsorption of LVX and DLX onto OGA-Pc-O-CMCS hydrogel.

Keywords:Hydrogel;Oxidized Gum Arabic;Fluoroquinolones (FQs) Antibiotic Adsorption;Pectin-O-Carboxymethyl Chitosan;Response Surface Methodology (RSM);Swelling Index

[References]

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[3] Felis E, Kalka J, Sochacki A, Kowalska K, Bajkacz S, Harnisz M, Korzeniewska E, Eur. J. Pharmacol., 866, 172813 (2020)

[4] Benarab N, Fangninou FF, Int. J. Sci. Res. Publ. IJSRP, 10 (2020)

[5] Onesios KM, Jim TY, Bouwer EJ, Biodegradation, 20(4), 441 (2009)

[6] Anglada A, Urtiaga A, Ortiz I, J. Chem. Technol. Biotechnol., 84(12), 1747 (2009)

[7] Kanakaraju D, Glass BD, Oelgemöller M, J. Environ. Manage., 219, 189 (2018)

[8] Li K, Lu X, Zhang Y, Liu K, Huang Y, Liu H, Environ. Res., 185, 109 (2020)

[9] Ali I, Alharbi OM, ALOthman ZA, Al-Mohaimeed AM, Alwarthan A, Environ. Res., 170, 389 (2019)

[10] Gu S, Kang X, Wang L, Lichtfouse E, Wang C, Environ. Chem. Lett., 17(2), 629 (2019)

[11] Baby R, Saifullah B, Hussein MZ, Nanoscale Res. Lett., 14(1), 1 (2019)

[12] Samaddar P, Kumar S, Kim KH, Polym. Rev., 59(3), 418 (2019)

[13] Iftekhar S, Ramasamy DL, Srivastava V, Asif MB, Sillanpää M, Chemosphere, 204, 413 (2018)

[14] Capanema NS, Mansur AA, Mansur HS, de Jesus AC, Carvalho SM, Chagas P, de Oliveira LC, Environ. Technol., 39(22), 2856 (2018)

[15] Bao Z, Xian C, Yuan Q, Liu G, Wu J, Adv. Healthc. Mater., 8(17), 190 (2019)

[16] Chen M, Ni Z, Shen Y, Xiang G, Xu L, Colloids Surf. A: Physicochem. Eng. Asp., 602, 125 (2020)

[17] Liang X, Ma C, Yan X, Zeng H, McClements DJ, Liu X, Liu F, Food Hydrocolloids, 102, 105 (2020)

[18] Amr M, Counts M, Kernan J, Mallah A, Mendenhall J, Van Wie B, Abu-Lail N, Gozen BA, Bioprinting, 22, 133 (2021)

[19] Perini M, Bertoldi D, Nardin T, Pianezze S, Ferrari G, Larcher R, Food Hydrocolloids, 105, 105 (2020)

[20] Sudalai A, Khenkin A, Neumann R, Org. Biomol. Chem., 13(15), 4374 (2015)

[21] Manjunath S, Kumar M, Chemosphere, 262, 127 (2021)

[22] Gong H, Liu M, Zhang B, Cui D, Gao C, Ni B, Chen J, Int. J. Biol. Macromol., 49(5), 1083 (2011)

[23] Huang GQ, Cheng LY, Xiao JX, Han XN, Colloid Polym. Sci., 293(2), 407 (2015)

[24] Tareq AZ, Hussein MS, Mustafa AM, Int. Res. J. Pure Appl., 12(4), 1 (2016)

[25] Gupta K, Jabrail FH, Carbohydr. Res., 341(6), 744 (2006)

[26] Drury JL, Mooney DJ, Biomaterials, 24(24), 4337 (2003)

[27] Sarafrazi M, Hamadanian M, Ghasemi AR, Mech. Mater., 138, 103 (2019)

[28] Sarker B, Papageorgiou DG, Silva R, Zehnder T, Gul-E-Noor F, Bertmer M, Kaschta J, Chrissafis K, Detsch R, Boccaccini AR, J. Mater. Chem. B, 2(11), 1470 (2014)

[29] Lach J, Water, 11(6), 1141 (2019)

[30] Reed BE, Matsumoto MR, Sep. Sci. Technol., 28, 2179 (1993)

[31] Carvajal-Bernal AM, Gomez-Granados F, Giraldo L, Moreno-Pirajan JC, Eur. J. Chem., 8(2), 112 (2017)

[32] Tzabar N, ter Brake H, Adsorption, 22(7), 901 (2016)

[33] Mouzam MI, Dehghan M, Asif S, Sahuji T, Chudiwal P, Saudi. Pharm. J., 19(2), 85 (2011)