This paper, mainly through designing a reinforced structure from the perspective of bionics and substituting a new heat exchange working medium for the traditional working medium, attempted to figure out the thermal performance of the waste heat recovery device. By means of numerical method, the following five factors, namely the effects of Reynolds number (Re=1,300-1,800), the new heat transfer medium (CuO-H2O nanofluids), the angular frequency of the bionic reinforced structure (ω=20 rad/s, ω=25 rad/s, ω=30 rad/s), the amplitude of the bionic reinforced structure (A=1 mm, A=2mm, A=3 mm), and the phase shift of the bionic reinforced structure (α=0° , 90° , 180° ) were probed so as to reveal their effects on the thermal performance of the waste heat recovery unit as well as the latent influencing mechanism. It was found that the improvement of the thermal transmission performance of the afterheat recovery unit synchronizes with the increase of angular frequency, amplitude and phase shift.