화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.106, 233-242, February, 2022
DOI10.1016/j.jiec.2021.10.031  Export Citation
Dual gate-keeping and reversible on-off switching drug release for anticancer therapy with pH- and NIR light-responsive mesoporous silicacoated gold nanorods
Ju Hyang Park1, Kyung Eun Sung1, Ki Hak Kim1, Jong Ryeol Kim1, Jongbok Kim2, 3, Geon Dae Moon4, †, and Dong Choon Hyun1, †
  • 1Department of Polymer Science and Engineering, School of Applied Chemical Engineering, Polymeric Nano-materials Laboratory, Kyungpook National University, Daegu 41566, South Korea
  • 2Department of Materials Science and Engineering, Kumoh National Institute of Technology, Gumi, Gyeongbuk 39177, Korea
  • 3Department of Energy Engineering Convergence, Kumoh National Institute of Technology, Gumi 39177, Korea
  • 4Dongnam Division, Korea Institute of Industrial Technology, Busan 46938, Korea
E-mail:,
This work reports the fabrication of AuNR@MSNs [i.e., gold nanorods (AuNRs) coated with mesoporous silica nanoshells (MSNs)] with independent sensitivities to pH and near-infrared (NIR) light for reversible on-off switching of drug release without premature drug leakage. The fabrication involves the incorporation of lauric acid (LA) as a thermosensitive gatekeeper, followed by the coating of tannic acid (TA) layers as a pH-sensitive gatekeeper. The protonation-deprotonation of the TA layers according to change in pH can result in their swelling.deswelling to induce pH-sensitive drug release, while the solid.liquid phase transition of LA by NIR light-induced heat generation in AuNRs enables the NIR light-controlled release of preloaded drug molecules. The interplay between these dual gatekeepers allows the release of pre-loaded drug from the AuNR@MSN-LA@TAs (i.e., AuNR@MSNs incorporating LA and TA) only at acidic conditions under NIR light irradiation, without premature drug leakage under inactive conditions (neutral pH or no NIR light). Moreover, the reversibility of the gatekeepers can make an on.off mannered drug release. Benefiting from the capability of the gatekeepers to induce pH-/temperature-sensitive release, along with the photothermal ability of AuNRs, the AuNR@MSN-LA@TAs can exhibit a satisfactory anticancer performance without undesired drug leakage.
Keywords:Gold nanorods;Mesoporous silica nanoshells;Gatekeeper;Cancer therapy;Drug release
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