화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korea-Australia Rheology Journal, Vol.33, No.3, 187-199, August, 2021
DOI10.1007/s13367-021-0016-y  Export Citation
Droplet-based microextraction . when to go with the flow?
Jae Bem You†
  • Department of Chemical Engineering, Kyungpook National University, Daegu, Republic of Korea
E-mail:
Over the last few decades, droplets have been used for enrichment of target compounds from various types of samples including water, body fluids, soils, and food. Leveraging the high surface area-to-volume ratio, droplets are excellent means of rapidly concentrating the target compounds. The droplet-based microextraction technologies reported so far can be categorized as static and continuous. For a static method, droplets are exposed to a given amount of sample while for a continuous method the sample is continuously fed by a flow and the droplets can either remain static or move with the sample flow. Both the extraction performance and types of analyses that can be used depend on whether the method is static or continuous microextraction. This review classifies various droplet-based microextraction techniques as either a static or continuous method and discusses the advantages and drawbacks of each.
Keywords:droplet;liquid-liquid microextraction;interface
  1. Al-Saidi HM, Emara AAA, J. Saudi Chem. Soc., 18, 745 (2014)
  2. Canselier JP, Delmas H, Wilhelm AM, Abismail B, J. Dispersion Sci. Technol., 23, 333 (2002)
  3. Chen C, Rengarajan V, Kjar A, Huang Y, Bioact. Mater., 6, 113 (2021)
  4. Chen H, Fang Q, Yin XF, Fang ZL, Lab Chip, 5, 719 (2005)
  5. Chen YY, Chen ZM, Wang HY, Lab Chip, 12, 4569 (2012)
  6. Choi H, Wei Z, You JB, Yang H, Zhang X, Langmuir, 37, 5290 (2021)
  7. Choi I, Yang YI, Kim YJ, Kim Y, Hahn JS, Choi K, Yi J, Langmuir, 24(6), 2597 (2008)
  8. Abadi DMM, Ashraf N, Chamsaz M, Shemirani F, Talanta, 99, 1 (2012)
  9. Dinh T, Phan H, Kashaninejad N, Nguyen T, Dao DV, Nguyen N, Adv. Mater. Interfaces, 5, 180076 (2018)
  10. Dong Z, Fang Q, TrAC Trends Anal. Chem., 124, 115812 (2020)
  11. Doulia DS, Anagnos EK, Liapis KS, Klimentzos DA, J. Hazard. Mater., 317, 135 (2016)
  12. Dyett B, Zhang Q, Xu Q, Wang X, Zhang X, ACS Cent. Sci., 4, 1511 (2018)
  13. Dyett BP, Zhang X, ACS Nano, 14, 10944 (2020)
  14. Dyett BP, Li M, Zhao H, Zhang X, J. Phys. Chem. C, 123, 29866 (2019)
  15. Feng J, Zhang X, Huang L, Yao H, Yang C, Ma X, Zhang S, Zhang X, Anal. Chem, 91, 5613 (2019)
  16. Garstecki P, Fuerstman MJ, Stone HA, Whitesides GM, Lab Chip, 6, 437 (2006)
  17. Gou Y, Jia Y, Wang P, Sun C, Sensors, 18, 1762 (2018)
  18. Gregory C, Veeman M, PLoS One, 8, e82307 (2013)
  19. Guan Y, Kisaalita W, Colloids Surf. B: Biointerfaces, 84, 35 (2011)
  20. Guo L, Nawi NB, Lee HK, Anal. Chem., 88, 8409 (2016)
  21. Haidas D, Bachler SS, Kohler M, Blank LM, Zenobi R, Dittrich PS, Anal. Chem., 91, 2066 (2019)
  22. He Y, Lee HK, J. Chromatogr. A, 1122, 7 (2006)
  23. Hinze JO, AIChE J., 1, 289 (1955)
  24. Jeannot MA, Cantwell FF, Anal. Chem., 68, 2236 (1996)
  25. Jin DQ, Zhu Y, Fang Q, Anal. Chem., 86, 10796 (2014)
  26. Jin DQ, Shi SW, Ma Y, Fang Q, Anal. Chem. 2020.
  27. Kertesz V, Van Berkel GJ, J. Mass Spectrom., 45, 252 (2010)
  28. Kim H, Min KI, Inoue K, Im DJ, Kim DP, Yoshida J, Science, 352(6286), 691 (2016)
  29. Kim J, Kim JY, Kim Y, Lee SJ, Kim JM, Anal. Chem., 89, 8662 (2017)
  30. Kiso Y, Nishimura Y, Kitao T, Nishimura K, J. Membr. Sci., 171(2), 229 (2000)
  31. Kokosa JM, TrAC Trends Anal. Chem., 71, 194 (2015)
  32. Kwak D, Lim JA, Kang B, Lee WH, Cho K, Adv. Funct. Mater., 23(42), 5224 (2013)
  33. Li M, Bao L, Yu H, Zhang X, J. Phys. Chem. C, 122, 8647 (2018)
  34. Li M, Byett B, Zhang X, Anal. Chem., 91, 10371 (2019)
  35. Li B, Dyett B, Yu H, Bansal V, Zhang X, Small, 15, 180468 (2019)
  36. Li M, Cao R, Dyett B, Zhang X, Small, 16, 200416 (2020)
  37. Li Q, Zhu Y, Zhang NQ, Fang Q, Sci. Rep., 6, 22654 (2016)
  38. Li Y, Zhang T, Liang P, Anal. Chim. Acta, 536, 245 (2005)
  39. Li Z, Kiyama A, Zeng H, Lohse D, Zhang X, Lab Chip, 20, 2965 (2020)
  40. Liang J, Mu TT, Electrophoresis, 41(16-17), 1413 (2020)
  41. Liu H, Dasgupta PK, Anal. Chem., 68, 1817 (1996)
  42. Liu W, Lee HK, Anal. Chem., 72, 4462 (2000)
  43. Liu Y, Hashi Y, Lin JM, Anal. Chim. Acta, 585, 294 (2007)
  44. Lu ZY, Peng SH, Zhang XH, Langmuir, 32(7), 1700 (2016)
  45. Mafra G, Vieira AA, Merib J, Anderson JL, Carasek E, Anal. Chim. Acta, 1063, 159 (2019)
  46. Makos P, Slupek E, Gebicki J, Microchem. J., 152, 104384 (2020)
  47. Mary P, Studer V, Tabeling P, Anal. Chem., 80, 2680 (2008)
  48. Nelson GL, Asmussen SE, Lines AM, Casella AJ, Bottenus DR, Clark SB, Bryan SA, Anal. Chem., 90, 8345 (2018)
  49. Paiva A, Craveiro R, Aroso I, Martins M, Reis RL, Duarte ARC, ACS Sustain. Chem. Eng., 2, 1063 (2014)
  50. Pano-Farias NS, Ceballos-Magana SG, Muniz-Valencia R, Jurado JM, Alcazar A, Aguayo-Villarreal IA, Food Chem., 237, 30 (2017)
  51. Pena-Pereira F, Lavilla I, Bendicho C, Food Chem., 119, 402 (2010)
  52. Pinheiro A, de S, da Rocha GO, de Andrade JB, Microchem. J., 99, 303 (2011)
  53. Qi T, Xu M, Yao Y, Chen W, Xu M, Tang S, Shen W, Kong D, Cai X, Shi H, Lee HK, Talanta, 220, 121388 (2020)
  54. Qian J, Yamada D, Wei Z, Yukisada R, Tagawa Y, Shaw JM, Zhang X, Adv. Mater. Technol., 5, 190074 (2020)
  55. Revzin A, Tompkins RG, Toner M, Langmuir, 19(23), 9855 (2003)
  56. Rezaee M, Yamini Y, Shariati S, Esrafili A, Shamsipur M, J. Chromatogr. A, 1216, 1511 (2009)
  57. Rosenfeld L, Lin T, Derda R, Tang SKY, Microfluid. Nanofluidics, 16, 921 (2014)
  58. Rutkowska M, Płotka-Wasylka J, Sajid M, Andruch V, Microchem. J., 149, 103989 (2019)
  59. Sajid M, TrAC Trends Anal. Chem., 106, 169 (2018)
  60. Santos LO, dos Anjos JP, Ferreira SLC, de Andrade JB, Microchem. J., 133, 431 (2017)
  61. Selmovic S, Piraino F, Bae H, Rasponi M, Redaelli A, Khademhosseini A, Lab Chip, 11, 2325 (2011)
  62. Shahvar A, Saraji M, Shamsaei D, Sens. Actuators B-Chem., 273, 1474 (2018)
  63. Shen H, Fang Q, Talanta, 77, 269 (2008)
  64. Shen H, Fang Q, Fang ZL, Lab Chip, 6, 1387 (2006)
  65. Shishov A, Bulatov A, Locatelli M, Carradori S, Andruch V, Microchem. J., 135, 33 (2017)
  66. Sun WH, Wei Y, Guo XL, Wu Q, Di X, Fang Q, Anal. Chem., 92, 8759 (2020)
  67. Tan H, Wooh S, Butt HJ, Zhang X, Lohse D, Nat. Commun., 10, 478 (2019)
  68. Tang S, Qi T, Ansah PD, Nalouzebi Fouemina JC, Shen W, Basheer C, Lee HK, TrAC Trends Anal. Chem., 108, 306 (2018)
  69. Tang S, Qi T, Xia D, Xu M, Xu M, Zhu A, Shen W, Lee HK, Anal. Chem., 91, 5888 (2019)
  70. Timmer B, Olthuis W, van den Berg A, Sens. Actuators B-Chem., 107, 666 (2005)
  71. Tirandazi P, Hidrovo CH, Sens. Actuators B-Chem., 267, 279 (2018)
  72. Tobiszewski M, Anal. Methods, 8, 2993 (2016)
  73. Trujillo-Rodriguez MJ, Pino V, Anderson JL, Talanta, 172, 86 (2017)
  74. van Erp R, Soleimanzadeh R, Nela L, Kampitsis G, Matioli E, Nature, 585(7824), 211 (2020)
  75. Wagli P, Chang YC, Homsy A, Hvozdara L, Herzig HP, de Rooij NF, Anal. Chem., 85, 7558 (2013)
  76. Wang N, Mao S, Liu W, Wu J, Li H, Lin JM, RSC Adv., 4, 11919 (2014)
  77. Wang XL, Zhu Y, Fang Q, Analyst, 139, 191 (2014)
  78. Wang X, Sun M, Ferguson SA, Hoff JD, Qin Y, Bailey RC, Meyerhoff ME, Angew. Chem.-Int. Edit., 58, 8092 (2019)
  79. Wen X, Deng Q, Guo J, Yang S, Spectroc. Acta Pt. A-Molec. Biomolec. Spectr., 79, 508 (2011)
  80. Williams SM, Liyu AV, Tsai CF, Moore RJ, Orton DJ, et al., Anal. Chem., 92, 10588 (2020)
  81. Xu L, Basheer C, Lee HK, J. Chromatogr. A, 1152, 184 (2007)
  82. Yan H, Liu B, Du J, Yang G, Row KH, J. Chromatogr. A, 1217, 5152 (2010)
  83. Yobas L, Martens S, Ong WL, Ranganathan N, Lab Chip, 6, 1073 (2006)
  84. You JB, Lohse D, Zhang X, Lab Chip, 21, 2574 (2021)
  85. Yu X, Chen B, He M, Wang H, Tian S, Hu B, Anal. Chem., 90, 10078 (2018)
  86. Zaruba S, Vishnikin AB, Skrlikova J, Andruch V, Anal. Chem, 88, 10296 (2016)
  87. Zeng B, Wang Y, Zhang X, Lohse D, J. Phys. Chem. C, 123, 5571 (2019)
  88. Zeng F, Duan W, Zhu B, Mu T Zhu L, Guo J, Ma X, Anal. Chem., 91, 1064 (2019)
  89. Zgola-Grzeskowiak A, Grzeskowiak T, TrAC Trends Anal. Chem., 30, 1382 (2011)
  90. Zhang J, Xu S, Li W, Chem. Eng. Process., 2012.
  91. Zhang L, Sun J, He H, Huang Y, Shi H, Chen W, Lab Chip, 21, 2217 (2021)
  92. Zhang XC, Wei ZW, Gong XY, Si XY, Zhao YY, Yang CD, Zhang SC, Zhang XR, Sci. Rep., 6, 24730 (2016)
  93. Zhang XC, Zhang Q, Zhao H, Ma X, Pan X, Feng J, Zhang S, Zhang R, Abliz Z, Zhang X, Anal. Chem., 90, 9897 (2018)
  94. Zhang X, Lu Z, Tan H, Bao L, He Y, Sun C, Lohse D, Proc. Natl. Acad. Sci., 112, 9253 (2015)
  95. Zhang X, Wei Z, Choi H, Hao H, Yang H, Adv. Mater. Interfaces, 8, 200120 (2021)
  96. Zhu Y, Zhang YX, Cai LF, Fang Q, Anal. Chem., 85, 6723 (2013)
  97. Zhu Y, Piehowski PD, Zhao R, Chen J, Shen Y, Moore RJ, et al., Nat. Commun., 9, 82 (2018)