화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korean Chemical Engineering Research, Vol.59, No.3, 379-392, August, 2021
DOI10.9713/kcer.2021.59.3.379  Export Citation
Taxus chinensis로부터 파클리탁셀 정제를 위한 개선된 아세톤-물 분별침전 공정 개발 및 그 동역학 및 열역학적 해석
Development of An Improved Acetone-Water Fractional Precipitation Process for Purification of Paclitaxel from Taxus chinensis and Its Kinetic and Thermodynamic Analysis
강회종, 김진현†
  • 공주대학교 화학공학부, 31080 충남 천안시 서북구 천안대로 1223-24
Hoe-Jong Kang, and Jin-Hyun Kim†
  • Department of Chemical Engineering, Kongju National University, Cheonan, 31080, Korea
E-mail:
초록
본 연구에서는 초음파 캐비태이션 버블와 가스 버블를 이용한 파클리탁셀의 개선된 아세톤-물 분별침전 공정을 개발하였다. 전통적 방법에 비해 침전에 소요되는 시간이 20~25배 단축되었다. 또한 파클리탁셀의 침전물 크기는 3.5~5.5배 감소하였으며 파클리탁셀의 확산 계수는 3.5~6.7배 증가하였다. 초음파 캐비태이션 버블을 이용한 침전의 경우 초음파 파워는 증가할수록, 침전 온도는 감소할수록 침전 속도 상수는 증가하였다. 가스 버블을 이용한 침전의 경우 가스 유량은 증가할수록, 침전 온도는 감소할수록 침전 속도 상수는 증가하였다. 열역학적 해석을 통해 개선된 분별침전은 비자발적 발열 공정이었다.
In this study, an improved acetone-water fractional precipitation process for paclitaxel using ultrasonic cavitation bubbles and gas bubbles was developed. Compared to the conventional method, the time required for precipitation has been reduced by 20~25 times. In addition, the particle size of paclitaxel decreased by 3.5~5.5 times and the diffusion coefficient of paclitaxel increased by 3.5~6.7 times. In the case of precipitation using ultrasonic cavitation bubbles, as the ultrasonic power increased and the temperature decreased, the precipitation rate constant increased. In the case of precipitation using gas bubbles, as the gas flow rate increased and the temperature decreased, the precipitation rate constant increased. Thermodynamic parameters revealed the exothermic, irreversible, and nonspontaneous nature of the improved fractional precipitation.
Keywords:Paclitaxel;Fractional precipitation;Ultrasound;Cavitation bubbles;Gas bubbles
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