화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.100, 63-74, August, 2021
DOI10.1016/j.jiec.2021.05.041  Export Citation
A study of synergetic carrier emulsion liquid membrane for the extraction of amoxicillin from aqueous phase using response surface methodology
Bingchuan Yan, Xiaojing Huang, Kai Chen, Hui Liu, Shanshan Wei, Yihai Wu, and Li Wang1, †
  • College of Safety and Environmental Engineering, Shandong University of Science and Technology, Qingdao 266590, China
  • 1College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, China
E-mail:
Amoxicillin (AMX) is the most commonly used antibiotic in life. AMX was extracted from aqueous solution by synergetic carrier emulsion liquid membrane (ELM) technology for the first time. The membrane phase of ELM was mainly composed of kerosene and butyl acetate. The carrier has consisted of Aliquat-336 and TOA, the surfactant was Span-80, and the membrane enhancer was liquid paraffin. And Na2CO3 and NaCl were used as the internal aqueous phase for extraction. Firstly, the basic structure and mechanism of emulsion were characterized and analyzed. And then, the center composite design (CCD) of response surface methodology (RSM) was used to optimize the operating conditions. The optimal values were: Aliquat-336 concentration (1.1% v/v), trioctylamine (TOA) concentration (8.6% v/v), and extraction time (15 min), AMX concentration (75 mg/L). A polynomial model was fitted to predict the extraction yield of AMX. Under the optimal operating conditions, the optimal extraction prediction value was 98.58%, the extraction actual value was 98.2%, and the recovery rate of AMX was 75.3%.
Keywords:Amoxicillin;Response surface method;Synergetic carrier;Emulsion liquid membrane
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