Two Transition Metal Complexes: Magnetic Properties and Treatment Effect via Focused High-Intensity Ultrasound on Alzheimer’s Disease

Chang-Lu Huo; Ting Yu; Cai-Ying Pei; Ling-Ling Liu; Ying-Rui Zhang; Ying-Li Zhang

Macromolecular Research, Vol.29, No.5, 376-382, May, 2021

DOI10.1007/s13233-021-9046-z Export Citation

Two Transition Metal Complexes: Magnetic Properties and Treatment Effect via Focused High-Intensity Ultrasound on Alzheimer’s Disease

Chang-Lu Huo, Ting Yu, Cai-Ying Pei¹, Ling-Ling Liu², Ying-Rui Zhang³, and Ying-Li Zhang^{3, †}

Department of Ultrasonography, Liaocheng People’s Brain Hospital, Liaocheng, Shandong, P. R. China
¹Department of Ultrasonography, Liaocheng People’s Hospital, Liaocheng, Shandong, P. R. China
²Department of Neurology, Liaocheng People’s Brain Hospital, Liaocheng, Shandong, P. R. China
³Department of Neurology, Liaocheng People’s Hospital, Liaocheng, Shandong, P. R. China

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Two novel coordination polymers (where Cu for the complex 1 and the Co for the complex 2) with distinct transition metal ions containing 4-(3,5-dicarboxylphenyl)-2- methylpyridine (H2L), the pyridyl-dicarboxylic acid ligand, have been produced under the solvothermal reaction conditions, and the two compounds’ performances and architectures were also characterized. The chemical formulae determined of two complexes are respectively [Cu(L)(H2O)]·H2O (1) and [Co3(L)2Cl2(H2O)2]·2H2O (2). Complex 1 exhibits a 2D network with a (3,6)-connected kgd topology based on the dinuclear [Cu2O2] units. In complex 2, the linear trinuclear [Co3(μ-Ocarboxylate)2(COO)2Cl2] units with mixed carboxylate and μ-Cl triple bridges are cross-linked by the L ligands into a 3D framework with a (3,6)-connected rtl topology. The complexes’ magnetic performances reflected that between consecutive metal ions, there exists the antiferromagnetic coupling. Their treatment activities on Alzheimer's disease (AD) via focused high-intensity ultrasound were evaluated. Firstly, the Annexin V-fluorescein isothiocyanate/propidium iodide staining was implemented for the assessment of the apoptotic neurons percentage after compounds treatment. Next, the Aβ accumulation in the neurons was also detected via employing the western blotting assay.

Keywords:coordination complexes;crystal structures;transition metal;antiferromagnetic coupling;alzheimer’s disease

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