A hybrid method with a microfin tube and TiO2/water nanofluid with various nanoparticles concentration has been investigated experimentally. The objectives of this work arc to characterize thermohydraulic including friction factor and thermal performance, and to develop correlation based on the experimental result. In general, adding nanopartides to the base fluid causes increased thermal performance. Pressure drop inside the microfin tube at TiO2/water concentrations of 0.05, 0.15, and 0.30 vol% were respectively 73%, 77%, and 80% higher than that in the smooth tube. Furthermore, the pressure drop increased with an increment in Re number. In this work, the developed correlation was proposed to predict practically Nu number. The present findings contribute to our understanding of how to enhance heat transfer using helical microfins inside tubes and nanofluids. (C) 2020 Elsevier B.V. All rights reserved.