In this paper, the impact of Al2O3-water nanofluid droplets on a hot surface in the film boiling regime is investigated numerically. The impact velocities are within a range so droplet disintegration does not occur. A sharp formulation of the level-set method is adopted for interface modeling. The effect of nanoparticles is taken into account, adopting single-phase and two-phase approaches. Increasing the volume fraction of nanoparticles leads to an increase in the droplet spreading radius. This effect is more notable at higher impact velocities. The main part of spreading radius enhancement is achieved only by a nanoparticle concentration of 1%. The contact time of nanofluid droplets is independent of impact velocity and increases with concentration of nanoparticles. The heat removal from the surface enhances considerably with volume fraction. However, the main part of this enhancement is obtained only by adding 1% of nanoparticles. At a specific volume fraction, the rate of heat removal enhancement is almost independent of the impingement velocity. The single-phase, volume of fluid and mixture models were compared and no significant difference was observed between the obtained results for spreading radius and contact time. At low impact velocities, three models present almost the same predictions for total heat removal from the surface. However, at higher impact velocities, different values are predicted by the models. (C) 2020 Elsevier B.V. All rights reserved.