The supercritical technology is a promising green process in the fields of medicine, cosmetics, food, and feed industries. However, the poor solubility of phospholipid in supercritical carbon dioxide (ScCO2) limits its application in some processes. In order to enhance the solubility, a modified phospholipid with ScCO2-philic group (eg, polyvinyl acetate), is designed and successfully synthesized. The solubility of the ScCO2-philic phospholipids in ScCO(2)with ethanol as cosolvent (0.5, 1.0, 2.0 mol%) is determined at the temperatures of 313.15, 318.15, 323.15, 328.15 K, and the pressure range of 9 to 15 MPa. The determination results indicate that the solubility of the modified phospholipid in ScCO(2)is much higher than that of the soybean phospholipids. Furthermore, five semiempirical equations, namely, Chrastil-G, MST-S, Sodeifian-Sajadian, Perez, and Reddy, are used to correlate and predict the experimental results. The average absolute relative deviations of the correlation equations are 6.91%, 7.08%, 6.06%, 2.62%, and 6.15%, respectively, indicating that the solubility data can be well predicted.