Poly(vinyl alcohol) (PVA) was modified with 3-aminopropyltriethoxysilane and was used for synthesis of poly(urethane-urea) microcapsules (PUUMc) with encapsulated maltogenic a-amylase (BaMa) (E. C. 3.2.1.133). The optimization of PVA modification factors and PUUMc synthesis conditions was performed. Chemical structure, porosity and thermostability of PUUMc which were obtained under various synthesis conditions were evaluated. Release rate of BaMa from PUUMc was slower and EI of BaMa was higher, when enzyme was encapsulated during PUUMc synthesis.