Catalysts Pd-NSMR and Ru-NSMR based on palladium and ruthenium nanoparticles deposited on a nanospherical mesoporous resorcinol-formaldehyde polymer are synthesized. It is shown that the average size of polymer particles is 220-250 nm and the average size of palladium and ruthenium nanoparticles is 7.2 and 2.2 nm, respectively. The catalysts are tested in guaiacol hydrogenation at a temperature of 200 degrees C and a hydrogen pressure of 4.0 MPa. It is demonstrated that the ruthenium catalyst shows higher activity in guaiacol hydrogenation.