Interface engineering by local polarization using piezoelectric(1-4), pyroelectric(5,6)and ferroelectric(7-9)effects has attracted considerable attention as a promising approach for tunable electronics/optoelectronics, human-machine interfacing and artificial intelligence. However, this approach has mainly been applied to non-centrosymmetric semiconductors, such as wurtzite-structured ZnO and GaN, limiting its practical applications. Here we demonstrate an electronic regulation mechanism, the flexoelectronics, which is applicable to any semiconductor type, expanding flexoelectricity(10-13)to conventional semiconductors such as Si, Ge and GaAs. The inner-crystal polarization potential generated by the flexoelectric field serving as a 'gate' can be used to modulate the metal-semiconductor interface Schottky barrier and further tune charge-carrier transport. We observe a giant flexoelectronic effect in bulk centrosymmetric semiconductors of Si, TiO(2)and Nb-SrTiO(3)with high strain sensitivity (>2,650), largely outperforming state-of-the-art Si-nanowire strain sensors and even piezoresistive, piezoelectric and ferroelectric nanodevices(14). The effect can be used to mechanically switch the electronics in the nanoscale with fast response (<4 ms) and high resolution (similar to 0.78 nm). This opens up the possibility of realizing strain-modulated electronics in centrosymmetric semiconductors, paving the way for local polarization field-controlled electronics and high-performance electromechanical applications.