A recent paper explored the separation of the close-boiling mixture 1,2 propanediol (PDO) and ethylene glycol (EG). The optimum operating pressure using a traditional single vessel was 282 kPa with a reboiler duty of 399 kW. However, the vapor-liquid equilibrium shifts with pressure such that higher pressure is favorable in the PDO-rich region. An interesting steady-state design was developed that splits the column into a high-pressure rectifier (4.9 bar) and a low-pressure stripper (2.38 bar). A compressor (32 kW) moves vapor from the top of the stripper into the bottom of the rectifier. The hot vapor leaving the top of the rectifier at 244 degrees C provides all the heat required in the reboiler at the base of the stripper (234 degrees C). This novel design reduces energy cost by 85%. An effective control structure for this complex process is developed in this paper. A small auxiliary reboiler and condenser are used to stabilize the system and to handle large disturbances in throughput and feed composition. (C) 2020 Elsevier Ltd. All rights reserved.