The addition of NO2 to Group IV (MO2), and Group VI (MO3)(n) (n = 1-3) nanoclusters was studied using both density functional theory (DFT) and coupled cluster theory (CCSD(T)). The structures and overall binding energetics were predicted for Lewis acid-base addition without transfer of spin (a physisorption-type process) and the formation of either cluster-ONO (HONO-like or bidentate bonding) or NO3- formation where for both the spin is transferred to the metal oxide clusters (a chemisorption-type process). Only chemisorption of NO2 is predicted to be thermodynamically allowed at temperatures >= 298 K for Group IV (MO2)(n) clusters with the formation of surface chemisorbed NO2 being by far the most energetically favorable. The ligand binding energies (LBEs) for physisorption and chemisorption on the TiO2 nanoclusters are consistent with computational studies of the bulk solids. Chemisorption is only predicted to occur for (CrO3), clusters in the form of a terminal nitrate containing species whereas the larger chemisorbed nitrate structures for (MoO3)(n) and (WO3)(n) were found to be metastable and unlikely to form in any appreciable amount at temperatures of 298 K and higher. NO2 is predicted to only be capable of physisorbing to (MoO3)(n) and (WO3)(n) at lower temperatures and therefore unlikely to bind NO2 at temperatures >= 298 K. Correlations between the (MO3)(n)NO2 ligand bond energies and the chemical properties of the parent (MO3)(n) clusters (Lewis acidity, ionization potentials, excitation energies, and M = O/M-O bond strengths) are described.