Hypothesis: Superlubricity is known to dramatically reduce frictional energy consumption and to improve service life of mechanical devices and biological systems. However, reduction of wear during the running-in period of friction pairs, especially under high contact pressures, still remains an unresolved issue affecting all machines. Experiments: Here the lubrication, adsorption, and conformational properties of hydrated ions and polyethylene glycol (PEG) mixtures were evaluated at different mass fractions and concentrations of PEG and salts by ball-on-disc tribometer, zeta-potential, quartz crystal microbalance with dissipation (QCM-D), and dynamic light scatting (DLS) analyses. Findings: These mixtures exhibited superlubricity between Si3N4 and sapphire surfaces in a wide range of concentrations and ions valency. Interestingly, a running-in phase shorter than 1 min and low wear rate of 1.85 mu m(3) /(N.m) were observed at contact pressures up to 555 MPa, significantly higher to earlier findings. PEG chains retain random coils filling the bulk of the interfacial film without strongly adsorbing on the interfaces but significantly increasing the viscosity of lubricating film, thereby favoring hydrodynamic lubrication. Hydrated ions are strongly adsorbed on the negatively charged ceramic surfaces, ensuring a sustained hydration effect maintaining superlubricity. The outstanding lubrication characteristics of the PEG/ions mixtures were attributed to the synergistic action of hydration and hydrodynamic lubrication, which appears as a promising avenue for developing new green lubricants and has implications for industrial and biological applications. (C) 2020 Elsevier Inc. All rights reserved.