Development of ease-fabricated and effectively self-disinfecting textile materials for antimicrobial and infection prevention has been urgently desired by both consumers and industry. However, some nonresponsive antibacterial agents finished fabrics may be harmful to human. To address this issue, we developed a facile finishing method to endow woven cotton fabrics (WCF) with light-driven antibacterial property. Here in, porphyrinic metal-organic frameworks (PCN-224) were in situ synthesized on WCF (termed PCN-224/WCF) and PCN-224/WCF was proven to be used for antibacterial photodynamic inactivation (aPDI). aPDI studies indicated no difference in bacterial inactivation, the inactivation was 99.9999% of Gram-negative Escherichia coif 8099 and Pseudomonas aeruginosa CMCC (B) 10104 as well as Gram-positive Staphylococcus aureus ATCC-6538 and Bacillus subtilis CMCC (B) 63501 under visible light illumination (500 W, 15 cm vertical distance, lambda >= 420 nm, 45 min). Cytotoxicity tests revealed PCN-224/WCF had low biological toxicity and good biocompatibility. Mechanism study revealed that singlet oxygen (O-1(2)) was produced by PCN-224/WCF and caused severe damage to bacteria which was observed from the SEM images. This study provided a facile guideline to functionalize cotton fabrics with responsive bactericidal property which showed great potential for new generation of textiles with practical applications. (C) 2020 Elsevier Inc. All rights reserved.