The solubility of cyproterone acetate in 14 pure solvents, such as methyl tert-butyl ether, xylene, 1-butanol, 1-propanol, tetrahydrofuran, ethanol, ethyl acetate, isopropanol, acetone, acetonitrile, dimethylformamide, methanol, water, and trichloromethane, and mixed solvents of water + ethanol have been determined at temperatures from 273.15 to 318.15 K by applying the analytical method of high-performance liquid chromatography. The solubility results in 14 solvents were fitted by the modified Apelblat equation, van't Hoff equation, lambda h equation, NRTL equation, UNIQUAC equation, and Wilson equation. The solubility results in the binary solvents of water + ethanol were fitted by the modified Apelblat equation, van't Hoff equation, lambda h equation, NRTL equation, UNIQUAC equation, Jouyban-van't Hoff equation, and Jouyban-Apelblat equation. The solubility of cyproterone acetate in 14 pure solvents and mixed solvents increased with increasing temperature. The solubility of cyproterone acetate in the mixed solvents increased with the increasing of the mole fraction of ethanol. The computed results by way of the modified Apelblat equation, van't Hoff equation, lambda h equation, NRTL equation, UNIQUAC equation, Jouyban-van't Hoff equation, and Jouyban-Apelblat equation were matched with the actual results. The actual results and computed results are very useful in the separation and synthesis process of cyproterone acetate.