Near-Infrared Laser-Responsive Photothermal Bubble-Generating PLA Nanoparticles for Controlled Drug Release

Hojoon Lee; Min Ah Kim; Chang-Moon Lee

Macromolecular Research, Vol.29, No.3, 224-229, March, 2021

DOI10.1007/s13233-021-9026-3 Export Citation

Near-Infrared Laser-Responsive Photothermal Bubble-Generating PLA Nanoparticles for Controlled Drug Release

Hojoon Lee¹, Min Ah Kim¹, and Chang-Moon Lee^{1, 2, †}

¹Department of Biomedical Engineering, Chonnam National University Graduated School, Yeosu, Jeonnam 59626, Korea
²Department of Biomedical Engineering, Chonnam National University, Yeosu, Jeonnam 59626, Korea

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Stimuli-responsive drug delivery systems can respond to specific external stimuli, resulting in improved treatment outcomes and reduced side effects from their controllable site-specific release ability. The aim of this study was to develop a thermo-responsive bubble-generating drug release platform by near-infrared (NIR) laser irradiation using melanin-perfluorohexane-methotrexate-polylactic acid (Mel @PFH@MT -PLA) nanoparticles. Mel@PFH@MTX-PLA nanoparticles were successfully prepared without precipitation or aggregation. By adjusting the amount of perfluorohexane (PFH), a size of Mel@PFH@MTX-PLA nanoparticles with optimal conditions was about 52.75 ± 1.41 nm. Due to the photothermal conversion properties of melanin, the temperature of the Mel@PFH@MTX-PLA nanoparticles was increased to about 59.2 oC after 7min of 808 nm NIR laser irradiation at a power density of 1.5 W/cm2. The NIR laser-induced temperature increase triggered additional drug release and caused the phase transition of PFH, resulting in dramatic bubble generation. The resultant Mel@PFH@MTX-PLA nanoparticles can be utilized in biomedical applications as promising carriers for localized and controlled drug delivery.

Keywords:near-infrared laser;stimuli-responsive drug release;thermo-responsive bubble-generating nanoparticles;melanin;photothermal effect

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[2] Zhu Y, Kaskel S, Ikoma T, Hanagata N, Microporous Mesoporous Mater., 123, 107 (2009)

[3] Kubo T, Tachibana K, Naito T, Mukai S, Akiyoshi K, Balachandran J, Otsuka K, ACS Biomater. Sci. Eng., 5, 759 (2018)

[4] Sun W, Jiang H, Wu X, Xu Z, Yao C, Wang J, Qin M, Jinag Q, Wang W, Shi D, Cao Y, Nano Res., 12, 115 (2019)

[5] Chen HC, Liu DY, Guo ZJ, Chem. Lett., 45(3), 242 (2016)

[6] Chen Z, Zhang Z, Chen M, Xie S, Wang T, Li X, J. Mater. Chem. B, 7, 1415 (2016)

[7] Xiong X, Xu Z, Huang H, Wang Y, Zhao J, Guo X, Zhou S, Biomaterials, 245, 119840 (2020)

[8] Chen X, Chen Y, Yan M, Qiu M, ACS Nano, 6, 2550 (2012)

[9] You J, Shao R, Wei X, Gupta S, Li C, Small, 6, 1022 (2010)

[10] Sadat ME, Baghvador MK, Dunn AW, Wagner HP, Ewing RC, et al., Appl. Phys. Lett., 105, 091903 (2014)

[11] Robinson JT, Tabakman SM, Liang YY, Wang HL, Casalongue HS, Vinh D, Dai HJ, J. Am. Chem. Soc., 133(17), 6825 (2011)

[12] Wang L, Shi J, Zhang H, Li H, Gao Y, Wang , Wang H, Li L, Zhang C, Chen C, Zhang Z, Zhang Y, Biomaterials, 34, 262 (2013)

[13] Cheng X, Sun R, Yin L, Chai Z, Shi H, Gao M, Adv. Mater., 29, 160489 (2017)

[14] Kim M, Kim HS, Kim MA, Ryu H, Jeong HJ, Lee CM, Macromol. Biosci., 17, 160037 (2017)

[15] Kim MA, Yoon SD, Kim EM, Jeong HJ, Lee CM, Nanotechnology, 29, 415101 (2018)

[16] Kim MA, Yoon SD, Lee CM, Int. J. Biol. Macromol., 103, 839 (2017)

[17] Jiang Q, Luo Z, Men Y, Yang P, Peng H, Guo R, Tian Y, Pang Z, Yang W, Biomaterials, 143, 29 (2017)

[18] Zhu D, Fan F, Huang C, Zhang Z, Qin Y, Lu L, Wang H, Jin X, Zhoa H, et al., Acta Biomater., 75, 386 (2018)

[19] Jose G, Lu YJ, Chen HA, Hsu HL, Hung JT, Anilkumar TS, Chen JP, J. Magn. Magn. Mater., 474, 355 (2019)

[20] Sahle FF, Gulfam M, Lowe TL, Drug Discov. Today, 23, 992 (2018)

[21] Chen KJ, Chaung EY, Wey SP, Lin KJ, Cheng F, Lin CC, et al., ACS Nano, 8, 5105 (2014)

[22] Desgouilles S, Vauthier C, Bazile D, Vacus J, Grossiord JL, Veillard M, Couvreur P, Langmuir, 19(22), 9504 (2003)

[23] Sheeran PS, Dayton PA, Scientifica, 2014 (2014)

[24] Slominski RM, Zmijewski MA, Slominski AT, Exp. Dermatol., 24, 258 (2015)

[25] Liu YL, Ai KL, Liu JH, Deng M, He YY, Lu LH, Adv. Mater., 25(9), 1353 (2013)

[26] Zhao Y, Song W, Wang D, Ran H, Wang R, Yao Y, Wang Z, Zheng Y, Li P, ACS Appl. Mater. Interfaces, 7, 14231 (2015)