The effects of various surface roughness geometrical properties including roughness height (5%, 10%, 15%), number (3, 6), and shape (rectangular and triangular) on the flow and heat transfer of slip-flow in trapezoidal microchannels were investigated. The effects of mentioned parameters on the heat transfer coefficient through the microchannel, average Nusselt number and pressure drop for Reynolds number of 5, 10, 15 and 20 were examined. The obtained results showed that increasing the roughness height and number increases the pressure drop due to higher stagnation effects before and after roughness elements and decreases the Nusselt number due to higher recirculation zones effects than obstruction effects. The most reduction in Nusselt number and the most increment in pressure drop occur at the roughness height of 15%, roughness number of 6 and Reynolds number of 20 by about 10.6% and 52.8% than the smooth microchannel respectively. (C) 2020 The Chemical Industry and Engineering Society of China, and Chemical industry Press Co., Ltd. All rights reserved.