Chemistry Letters, Vol.49, No.12, 1481-1483, 2020
Synthesis of CF3-Containing Isoindolinone Derivatives through Rhodium-catalyzed Oxidative Coupling of Benzamides with 2-Trifluoromethylacrylate
The oxidative coupling of benzamides with methyl 2-trifluoromethylacrylate proceeds smoothly under rhodium(III) catalysis to produce trifluoromethyl-substituted isoindolinone derivatives. The catalyst system [(CpRhCl2)-Rh-E](2)/AgSbF6 is effective for the oxidative coupling, while [Cp*RhCl2](2)/AgSbF6 leads to their redox-neutral coupling predominantly. The oxidative coupling reactions with related acrylates have also been examined.