TiO2 supported SBA-15 (xTi@SBA-15) materials with various high TiO2 loadings (x = 25, 50 and 70 wt%) have been used as support for impregnation of CoMo active phase for the hydrodesulfurization (HDS) of 4,6-di-methyldibenzothiophene (46DMDBT) as model molecule representative of gazole cuts. Compared to CoMoS supported over pure commercial TiO2 and conventional Al2O3, a higher total activity was measured corresponding to the presence of isomerization and dismutation reactions due to Bronsted acidity of TiO2. However, the HDS activity remains higher using alumina as support. Moreover, the DDS pathway was found favored to the HYD one with sulfided CoMo supported over xTi@SBA-15 catalysts contrary with alumina as support.