Cu-based catalysts have been variously used in the water gas shift reaction (WGSR) and methanol synthesis, both of which use carbon monoxide as a common reactant. According to the Bell-Evans-Polanyi principle, CO ad-sorption energies (E-ads,E-CO) directly affect the activation energies for CO hydrogenation. Thus, the understanding of the relationship between E-ads,E-CO and the chemical properties of the catalytic surface is fundamental to catalyst design. In particular, recent studies have shown that effective catalysts can be developed by controlling the exposed facets or forming alloys with other transition metal to enhance the mechanical and electronic characteristics. In bimetallic catalysts, two types of chemical effects are known to determine the adsorption energies: one is the "strain" effect caused by lattice mismatch and the other is the "ligand" effect, generated by the change in orbital electrons. We conducted calculations on Cu/M(100), (111), and (211) surfaces (M = Ni, Ir, Pd and Pt) by using spin-polarized density functional theory (DFT) calculations to find the dominant factor, as well as trends, affecting CO adsorption. Our calculations suggest the ligand effect is the dominant contribution to E-ads,E-CO, regardless of the type of facets. We also determined that the ligand contribution is caused by the loss of electrons from the surface Cu atoms. As a result, a proportional correlation between ligand contribution and electron charge transfer was observed. On investigating the strain effect on the (111) facet, we found that the results are consistent with d-band theory, while the E-ads,E-CO on (100) and (211) facets showed the opposite trend.