Zinc imidazolate framework-8 as a promising nitric oxide carrier

Junjira Tanum; Hyejoong Jeong; Moonhyun Choi; Daheui Choi; Kyungtae Park; Jong Bum Lee; Jinkee Hong

Journal of Industrial and Engineering Chemistry, Vol.91, 355-361, November, 2020

DOI10.1016/j.jiec.2020.08.021 Export Citation

Zinc imidazolate framework-8 as a promising nitric oxide carrier

Junjira Tanum, Hyejoong Jeong, Moonhyun Choi, Daheui Choi, Kyungtae Park, Jong Bum Lee^{1, †}, and Jinkee Hong^†

Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea
¹Department of Chemical Engineering, University of Seoul, 163 Seoulsiripdaero, Dongdaemungu, Seoul, 02504, Republic of Korea

E-mail:,

Uncontrollable release and unexpected release limit the use of nitric oxide (NO). To overcome this problem, we introduce ZIF-8 as a pH-responsive NO carrier. The flexible framework of ZIF-8 under the high-pressure condition causes the physically NO adsorption inside the SOD cage. ZIF-8 maintain the excellent gas storage ability under the physiological environment. The results show good pH-responsive ability. The gas could not be released out until the particle is in an acid condition. At low pH conditions, half of the gas is released in 1% of the total release duration. Interestingly, the half-release (t1/2) increases to 10% when the phosphate species exist in the acid surrounding. The gradual release can occur under neutral conditions with the existence of phosphate (t1/2 33%). From these results, we expect this ZIF-8 loading NO nanoparticles is lead to the design of innovative gas therapeutic delivery platforms using the advantage of the flexible framework for loading and releasing the gas molecule.

Keywords:Zinc imidazolate framework 8;Nitric oxide;Gas storage;pH-sensitive;Controlled gas release

[References]

Bogdan C, Nat. Immunol., 2, 907 (2001)
Carpenter AW, Schoenfisch MH, Chem. Soc. Rev., 41, 3742 (2012)
Jia F, Deng Y, Fang Y, Jin Q, Ji J, Bioconjug. Chem., 30, 583 (2019)
Ahonen MJR, Dorrier JM, Schoenfisch MH, ACS Infect. Dis., 5, 1327 (2019)
Jeong H, Park JH, Shin JH, Yoo YC, Park CY, Hong J, Chem. Mater., 30, 8528 (2018)
Tanum J, Jeong H, Heo J, Choi M, Park K, Hong J, Appl. Surf. Sci., 486, 452 (2019)
Stefanovic-Racic M, Stadler J, Evans CH, Arthritis Rheum., 36, 1036 (1993)
Schairer DO, Chouake JS, Nosanchuk JD, Friedman AJ, Virulence, 3, 271 (2012)
Wei G, Yang G, Wei B, Wang Y, Zhou S, Acta Biomater., 100, 365 (2019)
Li B, Ji P, Peng SY, Pan P, Zheng DW, Li CX, Sun YX, Zhang XZ, Adv. Mater., 2000376 (2020).
Bonavida B, Biochem. Pharmacol., 176, 113913 (2020)
Zheng HQ, Zhang YN, Liu LF, Wan W, Guo P, Nystrom AM, Zou XD, J. Am. Chem. Soc., 138(3), 962 (2016)
Wu Q, Li M, Tan L, Yu J, Chen Z, Su L, Ren X, Fu C, Ren J, Li L, Cao F, Liang P, Zhang Y, Meng X, Nanoscale Horiz., 3, 606 (2018)
Liang K, Richardson JJ, Doonan CJ, Mulet X, Ju Y, Cui J, Caruso F, Falcaro P, Angew. Chem.-Int. Edit., 56, 8510 (2017)
McKinlay AC, Xiao B, Wragg DS, Wheatley PS, Megson IL, Morris RE, J. Am. Chem. Soc., 130(31), 10440 (2008)
Pinto RV, Wang S, Tavares SR, Pires J, Antunes F, Vimont A, Clet G, Daturi M, Maurin G, Serre C, Angew. Chem.-Int. Edit., 132, 5173 (2020)
Moshoeshoe M, Nadiye-Tabbiruka M, Obuseng V, Am. J. Mater. Sci., 7, 196 (2017)
Perez-Pellitero J, Amrouche H, Siperstein FR, Pirngruber G, Nieto-Draghi C, Chaplais G, Simon-Masseron A, Bazer-Bachi D, Peralta D, Bats N, Chem. Eur., 16, 1560 (2010)
Fairen-Jimenez D, Moggach SA, Wharmby MT, Wright PA, Parsons S, Duren T, J. Am. Chem. Soc., 133(23), 8900 (2011)
Liang K, Ricco R, Doherty CM, Styles MJ, Bell S, Kirby N, Mudie S, Haylock D, Hill AJ, Doonan CJ, Falcaro P, Nat. Commun., 6, 7240 (2015)
Yun CY, Qin C, Wang XL, Yang GS, Shao KZ, Lan YQ, Su ZM, Huang P, Wang CG, Wang EB, Dalton Trans., 41, 6906 (2012)
Vasconcelos IB, da Silva TG, Militao GC, Soares TA, Rodrigues NM, Rodrigues MO, da Costa NB, Freire RO, Junior SA, RSC Adv., 2, 9437 (2012)
Velasquez-Hernandez MDJ, Ricco R, Carraro F, Limpoco FT, Linares-Moreau M, Leitner E, Wiltsche H, Rattenberger J, Schrottner H, Fruhwirt P, Cryst. Eng. Comm., 21, 4538 (2019)
Lee YR, Jang MS, Cho BY, Kwon HJ, Kim S, Ahn WS, Chem. Eng. J., 271, 276 (2015)
Im J, Yim N, Kim J, Vogt T, Lee Y, J. Am. Chem. Soc., 138(36), 11477 (2016)
Bhattacharyya S, Han R, Kim WG, Chiang Y, Jayachandrababu KC, Hungerford JT, Dutzer MR, Ma C, Walton KS, Sholl DS, Nair S, Chem. Mater., 30, 4089 (2018)
Jeong H, Park K, Yoo JC, Hong J, RSC Adv., 8, 38792 (2018)
Han S, Huang Y, Watanabe T, Dai Y, Walton KS, Nair S, Sholl DS, Meredith JC, ACS Comb. Sci., 14, 263 (2012)
Zhang C, Han C, Sholl DS, Schmidt J, J. Phys, Chem. Lett., 7, 459 (2016)
Han C, Zhang C, Tyminska N, Schmidt JR, Sholl DS, J. Phys. Chem. C, 122, 4339 (2018)
Gupta SK, Mohapatra M, Godbole SV, Natarajan V, RSC Adv., 3, 20046 (2013)
Jung SH, Oh E, Shim D, Park DH, Cho S, Lee B, Jeong Y, Lee KH, Jeong SH, Bull. Korean Chem. Soc., 30 (2009)
Malone-Povolny MJ, Maloney SE, Schoenfisch MH, Adv. Healthc. Mater., 8, 180121 (2019)
Ridnour LA, Thomas DD, Switzer C, Flores-Santana W, Isenberg JS, Ambs S, Roberts DD, Wink DA, Nitric Oxide, 19, 73 (2008)
Park D, Saravanakumar G, Kim WJ, Nitric Oxide-Releasing Functional Nanomaterials for Anticancer Therapy, Elsevier, pp.191 2019.

[1] Bogdan C, Nat. Immunol., 2, 907 (2001)

[2] Carpenter AW, Schoenfisch MH, Chem. Soc. Rev., 41, 3742 (2012)

[3] Jia F, Deng Y, Fang Y, Jin Q, Ji J, Bioconjug. Chem., 30, 583 (2019)

[4] Ahonen MJR, Dorrier JM, Schoenfisch MH, ACS Infect. Dis., 5, 1327 (2019)

[5] Jeong H, Park JH, Shin JH, Yoo YC, Park CY, Hong J, Chem. Mater., 30, 8528 (2018)

[6] Tanum J, Jeong H, Heo J, Choi M, Park K, Hong J, Appl. Surf. Sci., 486, 452 (2019)

[7] Stefanovic-Racic M, Stadler J, Evans CH, Arthritis Rheum., 36, 1036 (1993)

[8] Schairer DO, Chouake JS, Nosanchuk JD, Friedman AJ, Virulence, 3, 271 (2012)

[9] Wei G, Yang G, Wei B, Wang Y, Zhou S, Acta Biomater., 100, 365 (2019)

[10] Li B, Ji P, Peng SY, Pan P, Zheng DW, Li CX, Sun YX, Zhang XZ, Adv. Mater., 2000376 (2020).

[11] Bonavida B, Biochem. Pharmacol., 176, 113913 (2020)

[12] Zheng HQ, Zhang YN, Liu LF, Wan W, Guo P, Nystrom AM, Zou XD, J. Am. Chem. Soc., 138(3), 962 (2016)

[13] Wu Q, Li M, Tan L, Yu J, Chen Z, Su L, Ren X, Fu C, Ren J, Li L, Cao F, Liang P, Zhang Y, Meng X, Nanoscale Horiz., 3, 606 (2018)

[14] Liang K, Richardson JJ, Doonan CJ, Mulet X, Ju Y, Cui J, Caruso F, Falcaro P, Angew. Chem.-Int. Edit., 56, 8510 (2017)

[15] McKinlay AC, Xiao B, Wragg DS, Wheatley PS, Megson IL, Morris RE, J. Am. Chem. Soc., 130(31), 10440 (2008)

[16] Pinto RV, Wang S, Tavares SR, Pires J, Antunes F, Vimont A, Clet G, Daturi M, Maurin G, Serre C, Angew. Chem.-Int. Edit., 132, 5173 (2020)

[17] Moshoeshoe M, Nadiye-Tabbiruka M, Obuseng V, Am. J. Mater. Sci., 7, 196 (2017)

[18] Perez-Pellitero J, Amrouche H, Siperstein FR, Pirngruber G, Nieto-Draghi C, Chaplais G, Simon-Masseron A, Bazer-Bachi D, Peralta D, Bats N, Chem. Eur., 16, 1560 (2010)

[19] Fairen-Jimenez D, Moggach SA, Wharmby MT, Wright PA, Parsons S, Duren T, J. Am. Chem. Soc., 133(23), 8900 (2011)

[20] Liang K, Ricco R, Doherty CM, Styles MJ, Bell S, Kirby N, Mudie S, Haylock D, Hill AJ, Doonan CJ, Falcaro P, Nat. Commun., 6, 7240 (2015)

[21] Yun CY, Qin C, Wang XL, Yang GS, Shao KZ, Lan YQ, Su ZM, Huang P, Wang CG, Wang EB, Dalton Trans., 41, 6906 (2012)

[22] Vasconcelos IB, da Silva TG, Militao GC, Soares TA, Rodrigues NM, Rodrigues MO, da Costa NB, Freire RO, Junior SA, RSC Adv., 2, 9437 (2012)

[23] Velasquez-Hernandez MDJ, Ricco R, Carraro F, Limpoco FT, Linares-Moreau M, Leitner E, Wiltsche H, Rattenberger J, Schrottner H, Fruhwirt P, Cryst. Eng. Comm., 21, 4538 (2019)

[24] Lee YR, Jang MS, Cho BY, Kwon HJ, Kim S, Ahn WS, Chem. Eng. J., 271, 276 (2015)

[25] Im J, Yim N, Kim J, Vogt T, Lee Y, J. Am. Chem. Soc., 138(36), 11477 (2016)

[26] Bhattacharyya S, Han R, Kim WG, Chiang Y, Jayachandrababu KC, Hungerford JT, Dutzer MR, Ma C, Walton KS, Sholl DS, Nair S, Chem. Mater., 30, 4089 (2018)

[27] Jeong H, Park K, Yoo JC, Hong J, RSC Adv., 8, 38792 (2018)

[28] Han S, Huang Y, Watanabe T, Dai Y, Walton KS, Nair S, Sholl DS, Meredith JC, ACS Comb. Sci., 14, 263 (2012)

[29] Zhang C, Han C, Sholl DS, Schmidt J, J. Phys, Chem. Lett., 7, 459 (2016)

[30] Han C, Zhang C, Tyminska N, Schmidt JR, Sholl DS, J. Phys. Chem. C, 122, 4339 (2018)

[31] Gupta SK, Mohapatra M, Godbole SV, Natarajan V, RSC Adv., 3, 20046 (2013)

[32] Jung SH, Oh E, Shim D, Park DH, Cho S, Lee B, Jeong Y, Lee KH, Jeong SH, Bull. Korean Chem. Soc., 30 (2009)

[33] Malone-Povolny MJ, Maloney SE, Schoenfisch MH, Adv. Healthc. Mater., 8, 180121 (2019)

[34] Ridnour LA, Thomas DD, Switzer C, Flores-Santana W, Isenberg JS, Ambs S, Roberts DD, Wink DA, Nitric Oxide, 19, 73 (2008)

[35] Park D, Saravanakumar G, Kim WJ, Nitric Oxide-Releasing Functional Nanomaterials for Anticancer Therapy, Elsevier, pp.191 2019.