화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.89, 128-138, September, 2020
DOI10.1016/j.jiec.2020.03.036  Export Citation
Inhibition of Capsular Contracture of Poly (Dimethyl Siloxane) Medical Implants by Surface Modification with Itaconic Acid Conjugated Gelatin
Mallinath S. Birajdar1, Byung Hwi Kim2, Chanutchamon Sutthiwanjampa1, Shin Hyuk Kang3, Chan Yeong Heo3, 4, †, and Hansoo Park1, †
  • 1School of Integrative Engineering, Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul 06974, Republic of Korea
  • 2Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea
  • 3Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea
  • 4Interdisciplinary Program for Bioengineering, College of Engineering, Seoul National University, Seoul 08826, Republic of Korea
E-mail:,
Silicone implants have been widely used for the fabrication of medical devices and implants due to their biocompatibility and inert properties. However, the contact with biological fluids and the ensuing surface adsorption of proteins often lead to the formation of biofilms such as capsular contracture (CC), requiring the removal of implants. Therefore, there has been an urgent demand for surface modification with biomaterials having anti-inflammatory, anti-microbial, and anti-fibrotic activities to prevent CC on silicone implants. Here, Itaconic acid (IA) conjugated with PDMS (IA-PDMS) and IA-conjugated gelatin polymer (IA-GTpoly) conjugated with PDMS (IA-GTpoly-PDMS) with various concentrations were examined as a candidate for inhibition of CC on the surface of PDMS. The IA-PDMS and IA-GTpoly-PDMS surfaces showed lower inflammation, in vivo capsule thickness, and collagen density than the bare PDMS did. Our results demonstrated the significant potential of IA based materials for surface modification of PDMS to develop biocompatible surfaces for various biomedical devices.
Keywords:Poly (dimethylsiloxane);Itaconic acid;IA-GT polymer;Surface conjugation;Anti-fibrosis property
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