Development of novel cascade type crystallizer for continuous production of crystalline particles

Mana Koyama; Shoji Kudo; Shuntaro Amari; Hiroshi Takiyama

Journal of Industrial and Engineering Chemistry, Vol.89, 111-114, September, 2020

DOI10.1016/j.jiec.2020.06.021 Export Citation

Development of novel cascade type crystallizer for continuous production of crystalline particles

Mana Koyama, Shoji Kudo, Shuntaro Amari^†, and Hiroshi Takiyama

Department of Chemical Engineering, Tokyo University of Agriculture and Technology, 2-24-16, Naka-cho, Koganei, Tokyo, 184-8588, Japan

E-mail:

The introduction of a continuous crystallization process has been attracting attention for the pharmaceutical products. We designed a novel continuous crystallizer, which includes Couette-Taylor equipment integrated with MSMPR equipment in a cascading manner. Additionally, feed solutions were supplied to MSMPR and Couette.Taylor equipment to flexibly control the supersaturation of the MSMPR equipment, regardless of the supersaturation of Couette-Taylor equipment. In this study, the relationship between operating parameters in novel cascade.type crystallizer and final crystal quality was investigated. We found that the quality of the obtained crystalline particles depend on the flow-rate ratio of the feed solution supplied to Couette.Taylor equipment. Furthermore, the yield of crystalline products was improved using proposed crystallizer. Therefore, we expect proposed novel cascade.type crystallizer consisting of Couette-Taylor and MSMPR equipment to obtain crystalline products with various quality.

Keywords:Continuous crystallization;Cascade process;Crystal quality

[References]

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Chen J, Sarma B, Evans JMB, Myerson AS, Cryst. Growth Des., 11, 887 (2011)
Oullion M, Puel F, Fevotte G, Righini S, Carvin P, Chem. Eng. Sci., 62(3), 820 (2007)
Variankaval N, Cote AS, Doherty MF, AIChE J., 54(7), 1682 (2008)
Gao ZG, Rohani S, Gong JB, Wang JK, Engineering, 3, 343 (2017)
Majumder A, Processes, 6, 247 (2018)
Alvarez AJ, Myerson AS, Cryst. Growth Des., 10, 2219 (2010)
Su QL, Benyahia B, Nagy ZK, Rielly CD, Org. Process Res. Dev., 19, 1859 (2015)
Ridder BJ, Majumder A, Nagy ZK, Ind. Eng. Chem. Res., 53(11), 4387 (2014)
Sen M, Rogers A, Singh R, Chaudhury A, John J, Ierapetritou MG, Ramachandran R, Chem. Eng. Sci., 102, 56 (2013)
Griffin DW, Mellichamp DA, Doherty MF, Chem. Eng. Sci., 65(21), 5770 (2010)
Wong SY, Tatusko AP, Trout BL, Myerson AS, Cryst. Growth Des., 12, 5701 (2012)
Lawton S, Steele G, Shering P, Zhao LH, Laird I, Ni XW, Org. Process Res. Dev., 13, 1357 (2009)
Yang Y, Nagy ZK, Ind. Eng. Chem. Res., 54(21), 5673 (2015)
Lai TTC, Cornevin J, Ferguson S, Li NH, Trout BL, Myerson AS, Cryst. Growth Des., 15, 3374 (2015)
Luhrmann MC, Timmermann J, Schembecker G, Wohlgemuth K, Cryst. Growth Des., 18, 7323 (2018)
Nguyen AT, Joo YL, Kim WS, Cryst. Growth Des., 12, 2780 (2012)
Kim WS, J. Chem. Eng. Jpn., 47(2), 115 (2014)
Yamaguchi Y, Kim WS, Takiyama H, J. Chem. Eng. Jpn., 52(3), 308 (2019)
Andereck CDCD, Liu SS, Swinney HL, J. Fluid Mech., 164, 155 (1986)
Takiyama H, Matsuoka M, Powder Technol., 121(1), 99 (2001)

[Referenced By]

[1] Vetter T, Burcham CL, Doherty MF, Chem. Eng. Sci., 106, 167 (2014)

[2] Chen J, Sarma B, Evans JMB, Myerson AS, Cryst. Growth Des., 11, 887 (2011)

[3] Oullion M, Puel F, Fevotte G, Righini S, Carvin P, Chem. Eng. Sci., 62(3), 820 (2007)

[4] Variankaval N, Cote AS, Doherty MF, AIChE J., 54(7), 1682 (2008)

[5] Gao ZG, Rohani S, Gong JB, Wang JK, Engineering, 3, 343 (2017)

[6] Majumder A, Processes, 6, 247 (2018)

[7] Alvarez AJ, Myerson AS, Cryst. Growth Des., 10, 2219 (2010)

[8] Su QL, Benyahia B, Nagy ZK, Rielly CD, Org. Process Res. Dev., 19, 1859 (2015)

[9] Ridder BJ, Majumder A, Nagy ZK, Ind. Eng. Chem. Res., 53(11), 4387 (2014)

[10] Sen M, Rogers A, Singh R, Chaudhury A, John J, Ierapetritou MG, Ramachandran R, Chem. Eng. Sci., 102, 56 (2013)

[11] Griffin DW, Mellichamp DA, Doherty MF, Chem. Eng. Sci., 65(21), 5770 (2010)

[12] Wong SY, Tatusko AP, Trout BL, Myerson AS, Cryst. Growth Des., 12, 5701 (2012)

[13] Lawton S, Steele G, Shering P, Zhao LH, Laird I, Ni XW, Org. Process Res. Dev., 13, 1357 (2009)

[14] Yang Y, Nagy ZK, Ind. Eng. Chem. Res., 54(21), 5673 (2015)

[15] Lai TTC, Cornevin J, Ferguson S, Li NH, Trout BL, Myerson AS, Cryst. Growth Des., 15, 3374 (2015)

[16] Luhrmann MC, Timmermann J, Schembecker G, Wohlgemuth K, Cryst. Growth Des., 18, 7323 (2018)

[17] Nguyen AT, Joo YL, Kim WS, Cryst. Growth Des., 12, 2780 (2012)

[18] Kim WS, J. Chem. Eng. Jpn., 47(2), 115 (2014)

[19] Yamaguchi Y, Kim WS, Takiyama H, J. Chem. Eng. Jpn., 52(3), 308 (2019)

[20] Andereck CDCD, Liu SS, Swinney HL, J. Fluid Mech., 164, 155 (1986)

[21] Takiyama H, Matsuoka M, Powder Technol., 121(1), 99 (2001)