An anomalous increase of current was found in Fe-doped titania ceramics subjected to a constant field. It was proposed that the space-charge responsible for the current rise comes from the electrochemical reduction due to the blockage of O-2(g) --> O2-(s) ion transfer at cathode. This viewpoint was supported by evidence from the interior p-n junction, the electrode location-dependent anomalous current, the thermally stimulated current, the chemical shift of X-ray photoemission spectra (XPS), and the insulating intermediate layer Because of its large degradation rate as well as the small adsorption current, the Fe-doped titania ceramics offer an alternate material for the preparation of synaptic devices.