Powder Technology, Vol.369, 137-145, 2020
Development and characterization of curcumin-loaded solid self-emulsifying drug delivery system (SEDDS) by spray drying using Soluplus (R) as solid carrier
The objectives of the current work were (a) to investigate the suitability of soluplus (R) a hydrophilic polymer, as a carrier for the entrapment of curcuinin (CUR) SEDDS by the spray-drying process, and (b) to compare soluplus (R) with neusilin (R) US2, a hydrophobic high-capacity adsorbent for solid SEDDS. Both carriers produced free flowing powders with high CUR entrapment efficiency. When filled into capsules, approximately 95% of CUR was dissolved from the soluplus (R) powder within 120 min and only 41% from the neusilin (R) US2 base powder. When the powders were compressed into tablets, a slow CUR release was observed over 24 h. which varied as a function of compression force and the percentage of disintegrant used. In condusion, current study demonstrated the feasibility of using soluplus (R) as a carrier for the preparation of solid SEDDS with more favorable release profiles when compared to the conventional hydrophobic adsorbents. (C) 2020 Elsevier B.V. All rights reserved.
Keywords:Soluplus (R);Neusilin (R) US2;Curcumin;Spray drying;Self-emulsifying drug delivery systems (SEDDS);Controlled release