Liquid-vapor surface tension (ST) in nanopores attracts great attention in many industries because of the prosperity of nanoscience and nanotechnology. Here, considering the important emerging new physical phenomena induced by nanoconfinement effects, including curvature-dependent and shift-critical temperature (Tc)-dependent effects, the anomalous variation of ST in nanopores is captured from the molecular potential perspective. Furthermore, a simple analytical model is proposed to determine the ST in nanopores by correlating these two effects with an easily accessible parameter, that is, normalized pore dimension, which is the ratio of the pore radius to Lennard-Jones size parameter. The model is validated to be reliable for determining the STs of different substances both in the bulk phase as well as nanopores through comparison with the experimental results and molecular simulations. Our results show that the reduction of ST induced by the nanoconfinement effects is visible when the pore diameter is within tens of nanometers, and the reduction is more sensitive as the pore size decreases. In detail, the curvature-dependent effect is remarkable in the pores with diameters ranging from a few nanometers to tens of nanometers. Moreover, a simply generalized formula is obtained to determine the curvature-dependent effect and the Tolman length for different substances. The shift-Tc-dependent effect is not only related to the pore dimension but also depends on the temperature. As the pore size decreases, the critical temperature of confined fluids diverges significantly from the bulk values. While at high temperatures, the range of pore size impacted by the shiftTc-dependent effect is enlarged. Additionally, the nanoconfined STs of different substances are calculated and compared. Overall, the new model captures the underlying physics behind the variation of STs in nanopores and can determine the nanoconfined STs reasonably. Moreover, the simple formulation of the model is beneficial to the practical applications in many chemical engineering processes, such as chemical separation, nucleation phenomenon, and capillary condensation.