The application of nanomaterials in technology is limited by challenges in their processing into macroscopic structures with reliable and scalable methods. Herein, it is demonstrated that using scalable fabrication methods such as liquid-phase exfoliation, it is possible to produce dispersions of a wide variety of layered nanomaterials, including the first demonstration of boron nitride, with controllable and standardized size and thickness scaling. These can be used, as-produced, for Langmuir deposition, to create single layer films with tuneable density. Of particular importance, we show that the difference in edge chemistry of these materials dictates the film formation process, and therefore can be used to provide a generic fabrication methodology that is demonstrated for various layered nanomaterials, including graphene, boron nitride, and transition metal dichalcogenides. We show that this leads to controllable cancer cell growth on graphene substrates with different edge densities but comparable surface coverage, which can be produced on a statistically relevant cell study amount. This opens pathways for the generic fabrication of a range of layered nanomaterial films for various applications toward a commercially viable film fabrication technology.