The solubility of calcium sulfate dihydrate (CaSO4 center dot 2H(2)O) was measured in NaCl and glycerol aqueous solution with the mass fraction of glycerol 0-80% and molality of NaCl 0-6 m in the temperature range of 303.15 to 343.15 K and atmospheric pressure. The results showed that the dissolution of CaSO4 center dot 2H(2)O obviously decreased in aqueous solution with the increase of glycerol content. Addition of NaCl increased the solubility of CaSO4 center dot 2H(2)O in glycerol aqueous solution, and then solubility decreased with a further increase of molality in which the solubility maximum increase rate is 246.15%. Temperature has a little effect on solubility in the CaSO4 center dot 2H(2)O/NaCl/glycerol/H2O system. We also studied the physical properties (density and viscosity) of this system and used the least squares method to correlate the solubility, density, and viscosity with the molality of NaCl in a polynomial equation.