Ni-based catalysts were prepared using two hydroxyapatites (Ca-HA1, S-BET = 7 m(2)/g and Ca-HA2, S-BET = 60 m(2)/g) with different physico-chemical properties. The objective of the study was to evaluate the performance of these two materials as promising supports for dry reforming reaction (DRM) as well as to investigate the influence of different process parameters, such as temperature, pressure, time and catalyst pretreatment on the performance of these two catalysts. Thermodynamic calculations were performed to determine the conditions that would limit solid carbon deposit and favor the reactants conversion. Then, an experimental parametric study was carried out to investigate the impact of the temperature, pressure, catalyst pretreatment and support thermal treatment on the catalysts performance. The results showed that the catalyst pretreatment allowed the reduction of the nickel particles in a higher extent, which resulted in better catalytic performance when compared to the catalysts without pretreatment. High temperatures around 700 degrees C and low pressures around 1.6 bar were required to attain high CH4 and CO2 conversions around 70-80% as well as high H-2 and CO selectivity around 90% for 90 h of time on stream. In all cases, Ni/Ca-HA2 catalyst presented better catalytic performance than Ni/Ca-HA1 due to the presence of smaller nickel particles (10-20 nm), stronger basicity, higher density of basic sites (0.23 mmol g(-1)) as well as higher specific surface area (S-BET = 60 m(2)/g) of the Ca-HA2 support. Ni/Ca-HA2 catalyst was highly active (initial methane conversion: 75%) and relatively stable during 90 h of TOS and its catalytic behavior was comparable with the performance of Ni-based catalysts prepared with conventional supports reported in the literature. (C) 2019 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.