Bimetallic and polymetallic oxide-modified activated coke (AC) prepared by a one-step blending method and its desulfurization application were studied in this work. The bimetallic and polymetallic oxide-modified AC showed a good desulfurization performance, and Co2Ti2Mn1/AC achieved the highest sulfur capacity of 174.4 mg/g. Different metal oxides exhibited strong interactions and affected the SO2 removal of the comodified AC because of their varying physicochemical properties. The blending of Co2O3 and TiO2 benefitted the AC's pore structure formation (Co-5/AC 441 m(2)/g, Ti-5/AC 441 m(2)/g), whereas the coblending of Co2O3@TiO2 inhibited such formation (Co2.5Ti2.5/AC, 403 m(2)/g). However, the Co2O3@TiO2 comodification increased the surface functional groups, and the basic functional groups of Co2.5Ti2.5/AC exceeded those of Co-5/AC by 40.3%. The interactions of bimetallic oxide can be reformed by a third metal oxide. The SBET values of Co2Ti2Mn1/AC (461 m(2)/g) and Fe2Cu2Mn1/AC (365 m(2)/g) were significantly different from those of Co2.5Ti2.5/AC (403 m(2)/g) and Fe2.5Cu2.5/AC (429 m(2)/g), and MnO2 suppressed the positive impact of Co2O3@TiO2 on Co2Ti2Mn1/AC's surface functional groups. Moreover, the coblending of different metal oxides could change the metal oxides' reduction during the activation process.