In this work, Fe/Ni nanoparticles were produced through Fe(II) and Ni(II) reduction by NaBH4 and they were stabilized by a kind of prepared granular adsorbent (Fe/Ni@PGA). Fe/Ni@PGA as an environment-friendly activator was used to activate persulfate (PS) for the removal of ciprofloxacin from aqueous solution. Fe/Ni@PGA was systematically characterized via Brunauer-Emmett-Teller (BET) method, X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (MR). The effects of PS concentration, initial solution pH, Fe/Ni@PGA dosage, initial ciprofloxacin concentration, reaction temperature, anions, and natural organic matters on the removal of ciprofloxacin by Fe/Ni@PGA/PS were analyzed. The removal efficiency of ciprofloxacin by Fe/Ni@PGA/PS was 93.24% under an initial pH of 3.0, PS concentration of 10 mM, Fe/Ni@PGA dosage of 0.1 g, and reaction temperature of 30 degrees C. Fe/Ni@PGA could still exhibit high catalytic activity after nine cycles of regeneration. The removal mechanisms for ciprofloxacin by the Fe/Ni@PGA/PS system were proposed. In summary, the fe/Ni@PGARS system could be applied as a promising technology for ciprofloxacin removal. (C) 2020 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights reserved.