Sand control measures in horizontal wells are mainly based on screens. Horizontal wells have a certain length of horizontal displacement and the kick-off section with large curvature. Therefore, it is necessary to evaluate the safety of the screen downhole run before it runs into the hole, in order to minimize the running risk. In this paper, the pipe string is divided into sections, and the equivalent force for each elementary section is analyzed. Then, the axial force and friction resistance of the pipe string are calculated. According to the buckling criterion of the string and the mechanical strength theory, this paper evaluates whether the screen can safely and smoothly run down to the bottom of the well. This analytical method of solving the physical model is feasible and easy to understand and can be implemented using computer programming applications.