NIR dye-loaded mesoporous silica nanoparticles for a multifunctional theranostic platform: Visualization of tumor and ischemic lesions, and performance of photothermal therapy

Sang Bong Lee; Ho Won Lee; Bobby Aditya Darmawan; In-Kyu Lee; Sung Jin Cho; Jungwook Chin; Sang Kyoon Kim; Jong-Oh Park; Kil Soo Kim; Sang-Woo Lee; Jaetae Lee; Yong Hyun Jeon

Journal of Industrial and Engineering Chemistry, Vol.88, 99-105, August, 2020

DOI10.1016/j.jiec.2020.03.027 Export Citation

NIR dye-loaded mesoporous silica nanoparticles for a multifunctional theranostic platform: Visualization of tumor and ischemic lesions, and performance of photothermal therapy

Sang Bong Lee¹, Ho Won Lee², Bobby Aditya Darmawan^{1, 3}, In-Kyu Lee⁴, Sung Jin Cho⁵, Jungwook Chin⁵, Sang Kyoon Kim⁶, Jong-Oh Park^{1, 3}, Kil Soo Kim^{6, 7}, Sang-Woo Lee^{2, 4}, Jaetae Lee^{2, 4}, and Yong Hyun Jeon^{4, 6, †}

¹Korea Institute of Medical Microrobotics (KIMIRo), Gwangju 61011, South Korea
²Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu 702-210, South Korea
³School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, South Korea
⁴Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu 702-210, South Korea
⁵New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea
⁶Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 360-4, South Korea
⁷College of Veterinary Medicine, Kyungpook National University, Daegu 41566, South Korea

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We report the fabrication of multifunctional theranositic biomaterials via non-covalent, rapid, and effective encapsulation of 1,1'dioctadecyl-3,3,3' ,3'-tetrametylindotrucarbocyanine iodide (DIR)onto mesoporous silica nanoparticles by coating the surface of polyethylene glycol (PEG-DIR@MSN). PEG-DIR@MSNs exhibited great stability with excellent biocompatibility and photothermal conversion properties. PEG-DIR@MSN allowed for not only the detection of various types of tumor and ischemic lesions but also photothermal therapy against breast cancer in living mice, suggesting that PEGDIR@ MSN is a valuable multifunctional theranostic platform.

Keywords:Near infrared fluorescent dyes;Mesoporous silica nanoparticles;Theranostic biomaterials;Tumor detection;Ischemia;Photothermal therapy

[References]

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Lu J, Liong M, Zink JI, Tamanoi F, Small, 3, 1341 (2007)
Cheng SH, Lee CH, Chen MC, Souris JS, Tseng FG, Yang CS, Mou CY, Chen CT, Lo LW, J. Mater. Chem., 20, 6149 (2010)
Chen Y, Chen HR, Shi JL, Adv. Mater., 25(23), 3144 (2013)
Tang FQ, Li LL, Chen D, Adv. Mater., 24(12), 1504 (2012)
Vivero-Escoto JL, Slowing II, Trewyn BG, Lin VSY, Small, 6, 1952 (2010)
Mamaeva V, Sahlgren C, Linden M, Adv. Drug Deliv. Rev., 65, 689 (2013)
Hoffmann F, Cornelius M, Morell J, Froba M, Angew. Chem.-Int. Edit., 45, 3216 (2006)
Lai CY, Trewyn BG, Jeftinija DM, Jeftinija K, Xu S, Jeftinija S, Lin VSY, J. Am. Chem. Soc., 125(15), 4451 (2003)
Fu C, Qiang L, Liang Q, Chen X, Li L, Liu H, Tan L, Liu T, Ren X, Meng X, RSC Adv., 5, 46158 (2015)
Lei J, Yang L, Lu D, Yan X, Cheng C, Liu Y, Wang L, Zhang J, Adv. Opt. Mater., 3, 57 (2015)
Chatterjee DK, Gnanasammandhan MK, Zhang Y, Small, 6, 2781 (2010)
Gai SL, Yang PP, Li CX, Wang WX, Dai YL, Niu N, Lin J, Adv. Funct. Mater., 20(7), 1166 (2010)
Chen F, Goel S, Valdovinos HF, Luo H, Hernandez R, Barnhart TE, Cai W, ACS Nano, 9, 7950 (2015)
Chen F, Nayak TR, Goel S, Valdovinos HF, Hong H, Theuer CP, Barnhart TE, Cai W, Mol. Pharm., 11, 4007 (2014)
Cha BG, Jeong HG, Kang DW, Nam MJ, Kim CK, Choi IY, Ki SK, Kim SI, Han JH, Kim J, Nano Res., 11, 3582 (2018)
Chen YW, Peng K, Chou SW, Tseng YJ, Wu PC, Wang SK, Lee YW, Shyue JJ, Hsiao JK, Liu TM, Chou PC, Part. Part. Syst. Char., 34, 160041 (2017)
He Q, Shi J, J. Mater. Chem., 21, 5845 (2011)
Janib SM, Moses AS, MacKay JA, Adv. Drug Deliv. Rev., 62, 1052 (2010)
Chu LW, Huang YL, Lee JH, Huang LY, Chen WJ, Lin YH, Chen JY, Xiang R, Lee CK, Ping YH, J. Biomed. Opt., 19, 011018 (2013)
Nogues IFT, Goutayer M, Da Silva A, Guyon L, Djaker N, Josserand V, Neumann E, Bibette J, Vinet F, J. Biomed. Opt., 14, 054005 (2009)
Kim HL, Lee SB, Jeong HJ, Kim DW, RSC Adv., 4, 31318 (2014)
Shan L, Near-infrared Fluorescence 1,1-Dioctadecyl-3,3,3,3-tetramethylindo-tricarbocyanine Iodide (DiR)-labeled Macrophages for Cell Imaging, National Center for Biotechnology Information (US), 2010.
Du X, Wang X, Ning N, Xia S, Liu J, Liang W, Sun H, Xu Y, Exp. Ther. Med., 4, 221 (2012)
Eisenblatter M, Ehrchen J, Varga G, Sunderkotter C, Heindel W, Roth J, Bremer C, Wall A, J. Nucl. Med., 50, 1676 (2009)
Niiyama H, Huang NF, Rollins MD, Cooke JP, J. Vis. Exp., e1035 (2009).
Cheng X, Tian X, Wu A, Li J, Tian J, Chong Y, Chai Z, Zhao Y, Chen C, Ge C, ACS Appl. Mater. Interfaces, 7, 20568 (2015)

[Referenced By]

[1] Lee JE, Lee N, Kim T, Kim J, Hyeon T, Accounts Chem. Res., 44, 893 (2011)

[2] Lu J, Liong M, Zink JI, Tamanoi F, Small, 3, 1341 (2007)

[3] Cheng SH, Lee CH, Chen MC, Souris JS, Tseng FG, Yang CS, Mou CY, Chen CT, Lo LW, J. Mater. Chem., 20, 6149 (2010)

[4] Chen Y, Chen HR, Shi JL, Adv. Mater., 25(23), 3144 (2013)

[5] Tang FQ, Li LL, Chen D, Adv. Mater., 24(12), 1504 (2012)

[6] Vivero-Escoto JL, Slowing II, Trewyn BG, Lin VSY, Small, 6, 1952 (2010)

[7] Mamaeva V, Sahlgren C, Linden M, Adv. Drug Deliv. Rev., 65, 689 (2013)

[8] Hoffmann F, Cornelius M, Morell J, Froba M, Angew. Chem.-Int. Edit., 45, 3216 (2006)

[9] Lai CY, Trewyn BG, Jeftinija DM, Jeftinija K, Xu S, Jeftinija S, Lin VSY, J. Am. Chem. Soc., 125(15), 4451 (2003)

[10] Fu C, Qiang L, Liang Q, Chen X, Li L, Liu H, Tan L, Liu T, Ren X, Meng X, RSC Adv., 5, 46158 (2015)

[11] Lei J, Yang L, Lu D, Yan X, Cheng C, Liu Y, Wang L, Zhang J, Adv. Opt. Mater., 3, 57 (2015)

[12] Chatterjee DK, Gnanasammandhan MK, Zhang Y, Small, 6, 2781 (2010)

[13] Gai SL, Yang PP, Li CX, Wang WX, Dai YL, Niu N, Lin J, Adv. Funct. Mater., 20(7), 1166 (2010)

[14] Chen F, Goel S, Valdovinos HF, Luo H, Hernandez R, Barnhart TE, Cai W, ACS Nano, 9, 7950 (2015)

[15] Chen F, Nayak TR, Goel S, Valdovinos HF, Hong H, Theuer CP, Barnhart TE, Cai W, Mol. Pharm., 11, 4007 (2014)

[16] Cha BG, Jeong HG, Kang DW, Nam MJ, Kim CK, Choi IY, Ki SK, Kim SI, Han JH, Kim J, Nano Res., 11, 3582 (2018)

[17] Chen YW, Peng K, Chou SW, Tseng YJ, Wu PC, Wang SK, Lee YW, Shyue JJ, Hsiao JK, Liu TM, Chou PC, Part. Part. Syst. Char., 34, 160041 (2017)

[18] He Q, Shi J, J. Mater. Chem., 21, 5845 (2011)

[19] Janib SM, Moses AS, MacKay JA, Adv. Drug Deliv. Rev., 62, 1052 (2010)

[20] Chu LW, Huang YL, Lee JH, Huang LY, Chen WJ, Lin YH, Chen JY, Xiang R, Lee CK, Ping YH, J. Biomed. Opt., 19, 011018 (2013)

[21] Nogues IFT, Goutayer M, Da Silva A, Guyon L, Djaker N, Josserand V, Neumann E, Bibette J, Vinet F, J. Biomed. Opt., 14, 054005 (2009)

[22] Kim HL, Lee SB, Jeong HJ, Kim DW, RSC Adv., 4, 31318 (2014)

[23] Shan L, Near-infrared Fluorescence 1,1-Dioctadecyl-3,3,3,3-tetramethylindo-tricarbocyanine Iodide (DiR)-labeled Macrophages for Cell Imaging, National Center for Biotechnology Information (US), 2010.

[24] Du X, Wang X, Ning N, Xia S, Liu J, Liang W, Sun H, Xu Y, Exp. Ther. Med., 4, 221 (2012)

[25] Eisenblatter M, Ehrchen J, Varga G, Sunderkotter C, Heindel W, Roth J, Bremer C, Wall A, J. Nucl. Med., 50, 1676 (2009)

[26] Niiyama H, Huang NF, Rollins MD, Cooke JP, J. Vis. Exp., e1035 (2009).

[27] Cheng X, Tian X, Wu A, Li J, Tian J, Chong Y, Chai Z, Zhao Y, Chen C, Ge C, ACS Appl. Mater. Interfaces, 7, 20568 (2015)